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El autor critica la mantención de la atribución del Tribunal Constitucional relativa al control preventivo obligatorio de las leyes, contenida en el artículo 93, número 1, de la Constitución Política. Luego de aclarar su especial naturaleza jurídica, analiza y pondera las ventajas y desventajas d...

La discusión acerca de la idoneidad de la acción de inaplicabilidad para revisar los vicios de forma de las leyes generados en el proceso legislativo, que existía cuando esta acción era de competencia de la Corte Suprema, aún tiene asidero. El autor, luego de revisar la reacción de la doctrina a ...

Microglia are the immune cells in the central nervous system. After injury microglia release bioactive molecules, including cytokines and ATP, which modify the functional state of hemichannels (HCs) and gap junction channels (GJCs), affecting the intercellular communication via extracellular and ...

OBJETIVO: Determinar si las barreras y los elementos facilitadores de acceso a la atención de salud son transversales a distintas poblaciones, países y patologías, e identificar en qué etapas del proceso de acceso a la atención sanitaria se presentan con más frecuencia. MÉTODOS: Revisión sistemát...

OBJECTIVE: To determine whether health care access barriers and facilitators cut across different populations, countries, and pathologies, and if so, at which stages of health care access they occur most frequently. METHODS: A qualitative systematic review of literature published between 2000 and...

About a decade ago, the molecular determinants controlling the opening and closing of Cx43 gap junction channels have been identified. Advanced biophysical approaches revealed a critical role for structural rearrangements in the cytoplasmic loop and dimerization of the C-terminal tail, resulting ...

The conventional technique for percutaneous nephrolithotomy (PNL) ends by placing a nephrostomy tube within the access tract. However, feasibility and safety of tubeless PNL have been widely demonstrated. In this modification, a ureteral stent is usually left in place instead of the nephrostomy t...

Connexin hemichannel (Cx HC) opening is involved in physiological and pathological processes, allowing the cellular release of autocrine/paracrine signaling molecules. Linoleic acid (LA) is known to modulate the functional state of connexin46 (Cx46) HCs. However, the molecular mechanism involved ...

Coordinated interaction among cells is critical to develop the extremely complex and dynamic tasks performed by the central nervous system (CNS). Cell synchronization is in part mediated by connexins and pannexins; two different protein families that form gap junction channels and hemichannels. W...

OBJECTIVE: Analyze barriers and facilitators of access to prenatal care in pregnant urban adolescents between 15-19 years of age in Santiago, Chile. MATERIALS AND METHODS: Qualitative study based on grounded theory with 17 adolescent mothers. Eleven semi-structured interviews and one focus group ...

Given the enormous estimated burden of respiratory virus infections worldwide, a substantial number of research priorities exist in order to better understand their epidemiology, pathogenesis, prevention and clinical management across different populations and resource settings. New therapeutics ...