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Akol, G.W.O.Murray, M.Hirumi, H.Hirumi, K.Moloo, S.K.[Infectivity to cattle of metacyclic forms of Trypanosoma (Nannomonas) congolense propagated in vitro. I. Development of localised skin reactions following intradermal inoculation]Infectivity to cattle of metacyclic forms of Trypanosoma (Nannomonas) congolense propagated in vitro. I. Development of localised skin reactions following intradermal inoculation

Background Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa. We hypothesized that a vaccine targeting tick proteins that are involved in attachment and feeding might affect...


Olds, Cassandra L.Mwaura, S.Odongo, David O.Scoles, Glen A.Bishop, R.Daubenberger, C.A.[Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission]Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission

Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae is a severe disease widespread in Africa and Asia. Limited knowledge is available on the pathogenesis of this organism, mainly due to the lack of a robust in vivo challenge model and the means to do ...


Liljander, Anne M.Sacchini, F.Stoffel, M.H.Schieck, Elise G.Stokar-Regenscheit, N.Labroussaa, F.Heller, M.Salt, J.Frey, J.Falquet, L.Goovaerts, D.Jores, Joerg[Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro]Reproduction of contagious caprine pleuropneumonia reveals the ability of convalescent sera to reduce hydrogen peroxide production in vitro
Sitta, TatjanaHenson, Sonal P.Morrison, W. IvanToye, Philip G.[Similar levels of diversity in the gene encoding the p67 sporozoite surface protein of Theileria parva are observed in blood samples from buffalo and cattle naturally infected from buffalo]Similar levels of diversity in the gene encoding the p67 sporozoite surface protein of Theileria parva are observed in blood samples from buffalo and cattle naturally infected from buffalo

PPR remains a major challenge to smallholder farmers in Mali. To understand the drivers of low adoption of vaccination by farmers, we analyzed the socio-economic factors influencing farmer WTV during and in the absence of vaccination campaigns. Given that the costs associated with vaccination are...


Wane, AbdrahmaneDione, Michel M.Wieland, BarbaraRich, Karl M.Yena, A.S.Fall, A.[Willingness to vaccinate (WTV) and willingness to pay (WTP) for vaccination against peste des petits ruminants (PPR) in Mali]Willingness to vaccinate (WTV) and willingness to pay (WTP) for vaccination against peste des petits ruminants (PPR) in Mali

The drivers of vaccine development are many and varied. They include, for example, recognition of the burden of a vaccine-targeted disease, prioritisation of the multiple problems associated with a disease, consideration of the differing socio-economic situations under which vaccines are used, th...


Thomas, L.F.Bellet, C.Rushton, Jonathan[Using economic and social data to improve veterinary vaccine development: Learning lessons from human vaccinology]Using economic and social data to improve veterinary vaccine development: Learning lessons from human vaccinology

East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with...


Nyagwange, JamesNene, VishvanathMwalimu, Stephen M.Henson, Sonal P.Steinaa, LucillaNzau, Benjamin M.Tijhaar, EdwinPelle, Roger[Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro]Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro

Theileriosis, caused by parasitic protozoa of the genus Theileria parasites, are among the major tick-borne diseases of ruminant livestock. The largest economic losses are attributed in particular to those caused by the leukoproliferative species of Theileria: T. parva, T. annulata and T. lestoqu...


Ali, A.M.Salih, Diaeldin A.Njahira, Moses N.Hassan, S.K.Hussein, A.M.E.Liu, Z.Yin, H.Pelle, RogerSkilton, Robert A.[Genotyping of Theileria lestoquardi from sheep and goats in Sudan to support control of Malignant Ovine Theileriosis]Genotyping of Theileria lestoquardi from sheep and goats in Sudan to support control of Malignant Ovine Theileriosis

A live, attenuated vaccine is currently the only viable option to control of CBPP in Africa. It has been suggested that simple modifications to current vaccines and protocols might improve efficacy in the field. In this report we compared the current vaccine formulation with a buffered preparatio...


Nkando, I.Ndinda, J.Kuria, J.Naessens, JanMbithi, F.Schnier, C.Gicheru, M.McKeever, Declan J.Wesonga, H.O.[Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle]Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle

The study was designed to evaluate the immune response of chickens among different poultry management following challenge to live La Sota vaccine and further more investigated the lower antibody response detected in traditionally managed chicken, by testing the hypothesis that veterinary interven...


Abera, BerhanuLynch, Stacey E.Duguma, RetaDessie, TadelleBettridge, Judy M.Wigley, PaulChristley, Robert M.[Immunogenicity of the Newcastle disease virus vaccine La Sota, in introduced birds under intensive and extensive management conditions]Immunogenicity of the Newcastle disease virus vaccine La Sota, in introduced birds under intensive and extensive management conditions

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