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Casein kinase II from Trypanosoma congolense has been partially purified by chromatography on DEAE-cellulose and heparin-agarose and this subunit exhibits protein kinase activity with casein as the substrate. The enzyme adhered to both the DEAE-cellulose and heparin-agarose resins and was eluted ...

The studies described in this thesis were conducted to evaluate field application of the antigen-detection tube Enzyme Linked Immunosorbent Assay (ELISA) kit developed by Nantulya (1989) for diagnosis of Trypanosoma evansi infections in camels. The study was carried out on a herd of 100 camels in...

Since the anaemia of T. congolense infection, which has been shown to be mainly due to erythrocyte destruction by macrophages of the mononuclear phagocytic system, has been shown to be associated with poor reticulocyte response, a study was designed to verify if the unresponsiveness is attributab...

he many diverse and phenotypically unrelated diseases that occur with high frequency in aging mammalian species may have only a few primary causes. There is ample experimental evidence indicating that some of the essential and beneficial cellular metabolic reactions spontaneously generate free ra...

This project captures the problem of large microarray datasets and seeks to identify a statistical model of microarray hybridization intensity data that describes;differential regulation, sample variability and measurement noise. It also shows how one can use the data model to analyze the microar...

Bloodstream forms of African trypanosomes, which endocytose macromolecules exclusively through their flagellar pockets, contain an acid phosphatase (AcP) activity in this organelle. In the present thesis, AcP activity was demonstrated cytochemically in some intracellular vesicles and on the surfa...