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Article 2018

Autor: Lorca, M. Morales-Verdejo, C. Vásquez-Velásquez, D. Andrades-Lagos, J. Campanini-Salinas, J. Soto-Delgado, J. Recabarren-Gajardo, G. Mella, J.

The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of ...

Enlace original: http://repositorio.unab.cl/xmlui/handle/ria/8959

Repositorio Universidad Andrés Bello
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Lorca, M. ,  Morales-Verdejo, C. ,  Vásquez-Velásquez, D. ,  Andrades-Lagos, J. ,  Campanini-Salinas, J. ,  Soto-Delgado, J. ,  Recabarren-Gajardo, G. ,  Mella, J. ,  [Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles] ,  Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles
Article 2017-03

Autor: Apablaza, G. Montoya, L. Morales-Verdejo, C. Mellado, M. Cuellar, M. Lagos, C.F. Soto-Delgado, J. Chung, H. Pessoa-Mahana, C.D. Mella, J.

The beta(3) adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high affinity ligands have been made. Currently, Mirabegron is the only availa...

Enlace original: http://repositorio.unab.cl/xmlui/handle/ria/4255

Repositorio Universidad Andrés Bello
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Apablaza, G. ,  Montoya, L. ,  Morales-Verdejo, C. ,  Mellado, M. ,  Cuellar, M. ,  Lagos, C.F. ,  Soto-Delgado, J. ,  Chung, H. ,  Pessoa-Mahana, C.D. ,  Mella, J. ,  [2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity] ,  2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity
Article 2020

Introducción: La diabetes es una enfermedad metabólica crónica que afecta cerca de 425 millones de personas a nivel mundial. Su complicaciónmáscomún es la neuropatía diabética, una patología neurodegenerativa que afecta principalmente a nervios sensitivos y autonómicos. En distintos ...

Enlace original: https://repositorio.udd.cl/handle/11447/3363

Repositorio Institucional Universidad del Desarrollo
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Article 2019

Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a dangerassociated molecular pattern contributing to inflammatory pathologies. We show that HMGB1 derived from keratinocytes, but not myeloid cells, delays cutaneous wo...

Enlace original: https://repositorio.udd.cl/handle/11447/3205

Repositorio Institucional Universidad del Desarrollo
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