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International Laboratory for Research on Animal Diseases[The mechanisms by which cattle acquire immunity to trypanosomiasis]The mechanisms by which cattle acquire immunity to trypanosomiasis
Kemp, Stephen J.Tucker, E.M.Alberti, S.MacHugh, Niall D.Toye, Philip G.[A product of a second BoLA class I locus detected by a bovine monoclonal antibody]A product of a second BoLA class I locus detected by a bovine monoclonal antibody

The risk of infection by milk-borne brucellosis is one reason for public health regulations which discourage informal milk markets that sell unpasteurized milk. However, these regulations are not generally implemented in many developing countries. Kenya is a typical example, with over 85% of mil...


Kang'ethe, Erastus K.Arimi, S.M.Omore, Amos O.McDermott, John J.Nduhiu, J.G.Macharia, J.K.Githua, A.[The prevalence of antibodies to Brucella abortus in marketed milk in Kenya and its public health implications]The prevalence of antibodies to Brucella abortus in marketed milk in Kenya and its public health implications
Minami, J.Spooner, P.R.Irvin, A.D.Ocama, J.G.R.Dobbelaere, D.A.E.[An in vitro test for the possible differentiation of theilerial strains based on the use of monoclonal antibodies]An in vitro test for the possible differentiation of theilerial strains based on the use of monoclonal antibodies

Theileria are tick-transmitted, haemoprotozoan parasites infecting wild and domestic ungulates throughout many areas of the world. The most economically important species are T. parva and T. annulata which are pathogenic to cattle, and T. lestoquardi (syn hirci) which is pathogenic to sheep and g...


Skilton, Robert A.Musoke, A.J.Nene, VishvanathWasawo, D.P.S.Wells, C.W.Spooner, P.R.Bishop, Richard P.Osaso, J.Nkonge, C.Latif, A.Morzaria, S.P.[Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen]Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen

Field and experimental bovine infection sera were used in immunoblots of sporozoite and schizont lysates of Theileria parva to identify candidate diagnostic antigens. Four parasite antigens of Mr 67,000 (p67), 85,000 (the polymorphic immunodominant molecule, PIM), 104,000 (p104), and 150,000 (p15...


Katende, J.Morzaria, S.P.Toye, Philip G.Skilton, Robert A.Nene, VishvanathNkonge, C.Musoke, A.J.[An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule]An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule

In order to define whether the variable antigenic type RoTat 1.2 is restricted to Trypansoma evansi and could be used as antigen in serological tests to differentiate T. evansi from Trypansoma equiperdum, the appearance of RoTat 1.2-specific antibodies in rabbits, experimentally infected with T...


Claes, F.Verloo, D.Waal, D.T. deMajiwa, P.A.O.Baltz, T.Goddeeris, B.M.Buscher, P.[The expression of RoTat 1.2 variable surface glycoprotein (VSG) in Trypanosoma evansi and T. equiperdum]The expression of RoTat 1.2 variable surface glycoprotein (VSG) in Trypanosoma evansi and T. equiperdum

Serum Ig from Trypanosoma congolense-infected cattle were affinity-purified using immobilised trypanosome or non-trypanosome antigens (beta-galactosidase, cytochrome C and ferritin). The bound and unbound IgG and IgM fractions were collected and tested in ELISA for reactivity to each antigen. The...


Buza, J.Naessens, Jan[Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive]Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive

Understanding the basis of protective immunity to Cowdria ruminantium will facilitate the development of an effective subunit vaccine against heartwater in ruminants and contribute to a better definition of protective immune mechanisms to obligate intracellular pathogens in general. Until recentl...


Totte, P.Bensaid, A.Mahan, S.M.Martínez, D.McKeever, Declan J.[Immune responses to Cowdria ruminantium infections]Immune responses to Cowdria ruminantium infections

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