En el último tiempo, el término "Terapia Molecular Dirigida" ha sido utilizado cada
vez con más frecuencia, haciendo referencia al "Tratamiento de enfermedades
partiendo del conocimiento de la estructura y la función de la diana molecular, y
diseñando nue
Plant form is a product of emergent processes of cell division, patterning and morphogenesis. These fundamental processes remain poorly characterised in plants. However, engineering approaches can provide new tools and frameworks for the study and manipulation of plant development.
This dissertat...
Se estudiaron teórica y experimentalmente dos familias de polioxometalatos de valencia
mixta 3d0/3d1 y 4d0/4d1. La primera corresponde a una familia de polimetoxohexavanadatos de
tipo Lindqvist (familia V6). La segunda familia (4d0/4d1) corresponde a fosfo-dodecamolibdatos
(familia PMo12).
El an...
Two families of mixed-valence polyoxometalates of the 3d0/3d1and 4d0/4d1 type were studied, both, theoretical and experimental. The first family corresponds to a polyoxohexavanadates of the Lindqvist type (V6). The second, (4d0/4d1), corresponds to a phospho-dodecamolybdate family (PMo12).
The ...
Una importante α-hidroxicetona utilizada como precursor en la industria farmacéutica en la síntesis de fármacos con propiedades α y β adrenérgicas es el (R)-fenilacetilcarbinol, R-PAC. La producción de R-PAC usando la levadura Saccharomyces cerevisiae, glucosa y benzaldehído, fue el primer proces...
An important α-hydroxy ketone used as precursor in the pharmaceutical industry is (R)-phenylacetylcarbinol or R-PAC. It is used in the synthesis of drugs with α and β adrenergic properties. The production R-PAC using the yeast Saccharomyces cerevisiae, glucose and benzaldehyde was the first chira...
Several studies, using both molecular and ecological evidence, confirm that rafting contributes to population connectivity and range expansion of many species. However, there is also indication that the effectiveness of rafting transport of species to establish in new habitats...
This dissertation focuses on understanding the metabolic flexibility of a thermoacidophilic crenarchaeote, the mechanisms underlying its physiology, and the consequences for its ecology. Acidianus strain DS80 was isolated from an acidic spring in Yellowstone National Park (YNP) and displays versa...
Se denomina Mímica Vasculogénica (Vasculogenic Mimicry, VM) al proceso de formación de estructuras tubulares interconectadas, capaces de conducir fluido, por células no-endoteliales. Su presencia en biopsias tumorales ha sido asociada a una menor sobrevida general para los pacientes afectados. A ...
Vasculogenic mimicry (VM) describes a process by which cancer cells establish an alternative perfusion pathway in an endothelial cell-free manner. Despite its strong correlation with reduced patient survival, controversy still surrounds the existence of an in vitro model of VM. Furthermore, many ...
La medicina tradicional ha proporcionado a la humanidad remedios con fines de sanación a sus dolencias desde tiempos inmemoriales, algunas de estas propiedades terapéuticas han sido encontradas en ciertos registros empíricos egipcios, la mayoría de estos remedios provienen de plantas. En la actua...
Traditional medicine has provided humanity remedies for healing ailments since ancient times. Some of these therapeutic properties have been found to be registered in Egyptian data; the majority of these remedies come from plants. Currently, natural products are direct and important sources in th...
Las baterías de litio-aire presentan una elevada densidad energética (11428 Wh Kg-1) cercana a la densidad teórica de la gasolina, como sistemas “almacenadores" de energía. Sin embargo, su eficiencia real es mucho menor que el valor teórico debido principalmente a problemas con reacciones no dese...
Lithium-air batteries have a high energy density (11428 Wh Kg-1) close to the theoretical density of gasoline, as energy "storage" systems, however, their actual efficiency is much lower than the theoretical value due mainly to problems with unwanted reactions that generate overpotentials due to ...
El intercambio de segmentos (DS) corresponde a un mecanismo de oligomerización y plegamiento de proteínas, en el cual dos o más monómeros rompen contactos propios del estado nativo monomérico e intercambian parte de su estructura secundaria, restableciendo estos contactos de manera intermolecular...
Three-dimensional domain swapping is a protein folding and oligomerization mechanism, in which two or more monomers break native monomeric contacts and exchange part of their secondary structure, reestablishing these contacts in an intermolecular fashion by reaching an intertwined dimer or oligom...
