Preeclampsia (PE) es una patología del embarazo caracterizada por una placentación anómala generando una placenta hipoxica, siendo diagnosticada por la presencia de hipertensión arterial (sistólica > 140 mmHg y/o diastólica > 90 mmHg) después de la semana 20 gestación, coexistiendo con proteinuri...
Preeclampsia (PE) is a pathology of pregnancy characterized by an abnormal placentation generating a hypoxic placenta, being diagnosed by the presence of arterial hypertension (systolic> 140 mmHg and / or diastolic> 90 mmHg) after week 20 gestation, coexisting with proteinuria (> 300 mg / day) an...
La activación del receptor de estrógeno alfa (ERα) por estrógeno (E2) se ha asociado al origen y mantención del cáncer de mama. Sin embargo, los numerosos casos de resistencia al tratamiento con tamoxifeno, han impulsado la búsqueda de nuevas moléculas que tengan incidencia en esta patología. Ent...
The activation of estrogen receptor alpha (ERα) by estrogen (E2) has been associated with the origin and maintenance of breast cancer. However, the numerous cases of tamoxifen resistance have driven the search for new molecules that may have an impact on this neoplasia. Among them, GPR30 (recepto...
El cáncer es una de las principales causas de morbilidad y mortalidad en el mundo, y año a año aumentan las cifras de nuevos casos. Es un proceso complejo de proliferación celular no regulada, favorecido por la angiogénesis, que le brinda al tumor oxígeno, nutrientes y posibilidades de eliminar p...
La memoria episódica es el proceso de retención y reconstrucción de conocimiento a lo largo del tiempo para hechos, acontecimientos, personas, lugares, objetos. Se define como la memoria de “eventos en contexto”, haciendo referencia a que la información sobre eventos específicos está ligada a los...
Episodic memory is a process of retention and reconstruction of knowledge over time for events, events, people, places, objects, and is defined as the memory of events in context, making reference to the fact that information about specific events is linked to the spatial, temporal and situationa...
ABSTRACT
Obesity has turned into a world health burden, and Chile is not an exception. Obesity is a concerning illness not only because of its impact on daily life, but also because it is the root of several diseases. Metabolic dysfunctions are part of these diseases and among them, insulin resi...
Objective: Post-stroke Aphasia is a devastating condition associated with increased risk of depression and other comorbidities. It leads to long-term disability and a high number of patients are not able to return to work. There is an urgent need for better therapeutic interventions as well as ou...
Ovarian cancer is one of most lethal diseases in female population worldwide. The standard treatment (after surgical resection) is chemotherapy based mainly on carboplatin (CBDCA) and taxane. However, the main obstacle to a better prognosis is resistance to CBDCA. The nature of this resistance is...
