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A first-gneration subunit vaccine for East Coast fever based on the Theileria parva p67 sporozoite surface antigen is entering preliminary field trials. Intensive efforts are also focused on the identification of a schizont-specific omponen for incorporation in a second-generation multi-component...


McKeever, Declan J.Morrison, W. Ivan[Invited review Novel vaccines against Theileria parva: prospects for sustainability]Invited review Novel vaccines against Theileria parva: prospects for sustainability

Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle. We show that a soluble Escherichia coli recombinant version of p67 (p67635), in which a prokaryotic signal peptide replaces the e...


Bishop, Richard P.Nene, VishvanathStaeyert, J.Rowlands, G.J.Nyanjui, J.Osaso, J.Morzaria, S.P.Musoke, A.J.[Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites]Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites

Two novel baculovirus-derived recombinant Theileria parva p67 constructs were tested for their vaccine potential against East Coast fever. Boran calves were immunized with a his-GFP-p67 fusion protein (GFP:p67DeltaSS) or with GP64:p67C, a protein fusion between a C-terminal domain of p67 and th...


Kaba, S.A.Musoke, A.J.Schaap, D.Schetters, T.Rowlands, G.J.Vermeulen, A.N.Nene, VishvanathVlak, J.M.Oers, M.M. van[Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle]Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle

Heartwater, caused by the rickettsial organism Cowdria ruminantium, is a serious constraint to livestock development in much of sub-Saharan Africa. Traditionally, the disease has been controlled by the use of chemical acaricides to control the vector tick. The University of Florida/USAID-supporte...


Mukhebi, A.W.Chamboko, TafireyiO'Callaghan, C.J.Peter, T.F.Kruska, R.L.Medley, G.F.Mahan, S.M.Perry, Brian D.[An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe]An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe

East Coast fever (ECF) in cattle is caused by the tick-borne protozoan parasite Theileria parva. The major sporozoite surface antigen of T. parva (p67) is an important candidate for inclusion in a subunit vaccine. Recently, we reported the expression and production of different parts of p67 as f...


Kaba, S.A.Schaap, D.Roode, E.C.Nene, VishvanathMusoke, A.J.Vlak, J.M.Oers, M.M. van[Improved immunogenicity of novel baculovirus-derived Theileria parva p67 subunit antigens]Improved immunogenicity of novel baculovirus-derived Theileria parva p67 subunit antigens
Schubert, E.Sachse, K.Jores, JoergHeller, M.[Serological testing of cattle experimentally infected with Mycoplasma mycoides subsp. mycoides Small Colony using four different tests reveals a variety of seroconversion patterns]Serological testing of cattle experimentally infected with Mycoplasma mycoides subsp. mycoides Small Colony using four different tests reveals a variety of seroconversion patterns
Ole-MoiYoi, O.K.Nayar, A.Iams, K.P.Musoke, A.J.Yilma, T.[Molecular aspects of Theileria parva and approaches to vaccine development for animals]Molecular aspects of Theileria parva and approaches to vaccine development for animals
Tetley, L.Vickerman, K.Moloo, S.K.[Absence of a surface coat from metacyclic Trypanosoma vivax. Possible implications for vaccination against vivax trypanosomiasis]Absence of a surface coat from metacyclic Trypanosoma vivax. Possible implications for vaccination against vivax trypanosomiasis
Nene, VishvanathIams, K.P.Gobright, E.I.Musoke, A.J.[Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites]Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites

This paper reviews the past contributions of epidemiology and economics to the control of tick-borne infections of cattle in Africa. The factors affecting successful and unsuccessful control are evaluated on a gographical and on a production systems basis, with particular reference to Theileria p...


Perry, Brian D.Young, A.S.[The past and future roles of epidemiology and economics in the control of tick-borne diseases of livestock in Africa: The case of theileriosis]The past and future roles of epidemiology and economics in the control of tick-borne diseases of livestock in Africa: The case of theileriosis

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