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The tick population of Africa includes several important genera belonging to the family Ixodidae. Many of these ticks are vectors of protozoan and rickettsial pathogens including Theileria parva that causes East Coast fever, a debilitating cattle disease endemic to eastern, central and southern A...


Rothen, J.Githaka, Naftaly W.Kanduma, E.G.Olds, Cassandra L.Pflueger, V.Mwaura, S.Bishop, Richard P.Daubenberger, C.A.[Matrix-assisted laser desorption/ionization time of flight mass spectrometry for comprehensive indexing of East African Ixodid tick species]Matrix-assisted laser desorption/ionization time of flight mass spectrometry for comprehensive indexing of East African Ixodid tick species

Theileria parva is a protozoan parasite that causes the disease East Coast fever in cattle which results in major economic losses in Eastern, Central and Southern Africa. Efforts to generate vaccines involve measurements of cytotoxic activity since CD8 cells are believed to be responsible for pro...


Wendoh, J.Waihenya, R.Saya, R.Awino, EliasNene, VishvanathSteinaa, Lucilla[Perforin expression in Theileria parva specific Cytotoxic T Cells correlates with Cytotoxicity]Perforin expression in Theileria parva specific Cytotoxic T Cells correlates with Cytotoxicity

Protective immunity induced by the infective sporozoite stage of Theileria parva indicates a potential role for antibodies directed against conserved serologically reactive regions of the major sporozoite surface antigen p67 in vaccination to control the parasite. We have examined the allelic var...


Obara, I.Ulrike, S.Musoke, A.J.Spooner, P.R.Jabbar, A.Odongo, D.Kemp, Stephen J.Silva, J.C.Bishop, Richard P.[Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva]Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva

In natural populations, individuals may be infected with multiple distinct pathogens at a time. These pathogens may act independently or interact with each other and the host through various mechanisms, with resultant varying outcomes on host health and survival. To study effects of pathogens and...


Thumbi, S.M.Bronsvoort, B.M. de C.Poole, Elizabeth J.Kiara, Henry K.Toye, Philip G.Mbole-Kariuki, Mary N.Conradie, I.Jennings, A.Handel, I.G.Coetzer, J.A.W.Steyl, J.C.A.Hanotte, Olivier H.Woolhouse, Mark E.J.[Parasite co-infections and their impact on survival of indigenous cattle]Parasite co-infections and their impact on survival of indigenous cattle

Chickens raised under village production systems are exposed to a wide variety of pathogens, and current or previous infections may affect their susceptibility to further infections with another parasite, and/or can alter the manifestation of each infection. It is possible that co-infections may ...


Bettridge, Judy M.Lynch, Stacey E.Brena, M.C.Melese, K.Dessie, TadelleTerfa, Z.G.Desta, T.Rushton, S.Hanotte, Olivier H.Kaiser, P.Wigley, PaulChristley, Robert M.[Infection-interactions in Ethiopian village chickens]Infection-interactions in Ethiopian village chickens

We describe a horizontal survey of African swine fever virus (ASFV) prevalence and risk factors associated with virus infection in domestic pigs in two contrasting production systems in Kenya. A free range/tethering, low input production system in Ndhiwa District of South-western Kenya is compare...


Okoth, Edward A.Gallardo, C.Macharia, J.M.Omore, Amos O.Pelayo, V.Bulimo, D.W.Arias, MarisaKitala, P.Baboon, K.Lekolol, I.Mijele, D.Bishop, Richard P.[Comparison of African swine fever virus prevalence and risk in two contrasting pig-farming systems in South-west and Central Kenya]Comparison of African swine fever virus prevalence and risk in two contrasting pig-farming systems in South-west and Central Kenya

Abstract Contagious bovine pleuropneumonia (CBPP) is an economically important disease in most of sub-Saharan Africa. A conjoint analysis and ordered probit regression models were used to measure the preferences of farmers for CBPP vaccine and vaccination attributes. This was with regard to inclu...


Kairu-Wanyoike, S.W.Kaitibie, S.Taylor, N.M.Gitau, G.K.Heffernan, C.L.Schnier, C.Kiara, Henry K.Taracha, E.A.McKeever, Declan J.[Exploring farmer preferences for contagious pleuropneumonia vaccination: A case study in Narok district of Kenya]Exploring farmer preferences for contagious pleuropneumonia vaccination: A case study in Narok district of Kenya

Contagious bovine pleuropneumonia (CBPP) is a cattle disease that has hampered the development of the livestock sector in sub-Saharan Africa. Currently, vaccination with a live vaccine strain is its recommended control measure although unofficial antimicrobial use is widely practiced. Here, model...


Ssematimba, A.Jores, JoergMariner, Jeffrey C.[Mathematical modelling of the transmission dynamics of contagious bovine pleuropneumonia reveals minimal target profiles for improved vaccines and diagnostic assays]Mathematical modelling of the transmission dynamics of contagious bovine pleuropneumonia reveals minimal target profiles for improved vaccines and diagnostic assays

This study was conducted to (i) determine the prevalence of African Animal Trypanosomosis (AAT) in tsetse challenged areas, (ii) compare conventional with qPCR detection systems and (iii) evaluate the host genetic background and biology as risk factors. AAT prevalence studies are often confronted...


Silbermayr, K.Li, F.Soudre, A.Muller, S.Sölkner, J.[A novel qPCR assay for the detection of African animal trypanosomosis in trypanotolerant and trypanosusceptible cattle breeds]A novel qPCR assay for the detection of African animal trypanosomosis in trypanotolerant and trypanosusceptible cattle breeds

CBPP is an important transboundary disease in sub-Saharan Africa whose control is urgent. Participatory data collection involving 52 focus group discussions in 37 village clusters and key informant interviews, a cross-sectional study involving 232 households and a post-vaccination follow up invol...


Kairu-Wanyoike, S.W.Kiara, Henry K.Heffernan, C.L.Kaitibie, S.Gitau, G.K.McKeever, Declan J.Taylor, N.M.[Control of Contagious Bovine Pleuropneumonia: Knowledge, attitudes, perceptions and practices in Narok District of Kenya]Control of Contagious Bovine Pleuropneumonia: Knowledge, attitudes, perceptions and practices in Narok District of Kenya

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