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Background: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile ...


Cabrera, D.Cabello-Verrugio, C.Solís, N.Martín, D.S.Cofré, C.Pizarro, M.Arab, J.P.Abrigo, J.Campos, F.Irigoyen, B.Carrasco-Avino, G.Bezares, K.Riquelme, V.Riquelme, A.Arrese, M.Barrera, F.[Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation]Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation

Immobilization is a form of disuse characterized by a loss of strength and muscle mass. Among the main features are decreased IGF-1/Akt signalling and increased ubiquitin-proteasome pathway signalling, which induce greater myosin heavy chain degradation. Activation of the classical renin-angioten...


Morales, M.G.Abrigo, J.Acuna, M.J.Santos, R.A.Bader, M.Brandan, E.Simon, F.Olguin, H.Cabrera, D.Cabello-Verrugio, C.[Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas]Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

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