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Human chromosome (Chr) 18(HSA 18) contains approximately 85 million base pains of DNA. Thirty genes and pseudogenes have been mapped to HSA 18 by somatic cell genetics or in situ hybridization. Two bovine genes - Yamaguchi sacroma viral oncogene homology 1 (YESI) and desmocollin type 1 (DSC1) - h...


Agaba, MorrisKemp, Stephen J.Barendse, W.Teale, A.J.[Comparative mapping in cattle of genes located on human chromosome 18]Comparative mapping in cattle of genes located on human chromosome 18

A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...


Nilsson, P.H.Kang'a, S.Rottengatter, K.Suedbeck, U.Iraqui, F.Mwakaya, J.Mwangi, D.Womack, J.E.Goldammer, T.Schwerin, M.Bradley, D.Agaba, MorrisSugimoto, K.Gelhaus, A.Horstmann, R.Teale, A.J.Kemp, Stephen J.Hanotte, Olivier H.[Radiation hybrid maps of candidate trypanotolerance regions in cattle]Radiation hybrid maps of candidate trypanotolerance regions in cattle

Background: The history of African indigenous cattle and their adaptation to environmental and human selection pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards understanding the genomic basis of productivity and adaptation to s...


Kim, JaeminHanotte, Olivier H.Okeyo Mwai, AllyDessie, TadelleSalim, BashirDiallo, BoubacarAgaba, MorrisKwondo KimWoori KwakSamsun SungSeo, MinseokJeong, HyeonsooKwon, TaehyungTaye, MengistieSong, Ki-DukLim, DajeongSeoae ChoLee, Hyun-JeongDuhak YoonSung Jong OhKemp, Stephen J.Hak-Kyo LeeHeebal Kim[The genome landscape of indigenous African cattle]The genome landscape of indigenous African cattle

High-through put technologies inevitably produce vast quantities of data. This presents challenges in terms of developing effective analysis methods, particularly where the analysis involves combining data derived from different experimental technologies. In this investigation, a systematic appro...


Rennie, C.Hulme, H.Fisher, P.Halp, L.Agaba, MorrisNoyes, H.A.Kemp, Stephen J.Brass, A.[A systematic, data-driven approach to the combined analysis of microarray and QTL data]A systematic, data-driven approach to the combined analysis of microarray and QTL data

It is known that different breeds of cattle display differential susceptibilities to Trypanosome congolense infections, and that N'Dama cattle remain more productive after infection than Boran cattle which are more susceptible to T. congolense. Macrophages from both breeds were cultured in vitro ...


Kazuhiro, Y.Agaba, MorrisIraqi, F.A.Naessens, Jan[Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense]Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense

Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and...


Hanotte, Olivier H.Ronin, Y.Agaba, MorrisNilsson, P.Gelhaus, A.Horstmann, R.Sugimoto, Y.Kemp, Stephen J.Gibson, John P.Korol, A.Soller, M.Teale, A.J.[Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle]Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle

Interspecies hybridization of bovids occurs between domestic cattle and at least three other species; American bison (Bison bison), yak (Bos grunniens) and banteng (Bos banteng). Birth of a cattle × buffalo (Bubalus bubalis) hybrid has reportedly occurred in Russia and in China, but these reports...


Owiny, O.D.Barry, D.M.Agaba, MorrisGodke, R.A.[In vitro production of cattle × buffalo hybrid embryos using cattle oocytes and African buffalo (Syncerus caffer caffer) epididymal sperm]In vitro production of cattle × buffalo hybrid embryos using cattle oocytes and African buffalo (Syncerus caffer caffer) epididymal sperm
Hanotte, Olivier H.Korol, A.Agaba, MorrisNilsson, P.Gelhaus, P.Horstmann, R.Sugimoto, Y.Kemp, Stephen J.Soller, J.Teale, A.J.[Mapping of QTL controlling resistance to trypanosomosis in N'Dama X Boran cattle]Mapping of QTL controlling resistance to trypanosomosis in N'Dama X Boran cattle

Uniquely selected breeds bred over thousands of years of domestication in awide range of environments have been declared extinct over the last century. Still morebreeds are at risk of becoming extinct and the rate continues to accelerate. Assessing thecurrent status and possible future dynamics o...


Bett, R.C.Okeyo Mwai, AllyMalmfors, B.Johansson, K.Agaba, MorrisKugonza, D.R.Bhuiyan, A.K.F.H.Filho, A.E.V.Mariante, A.S.Mujibi, F.D.N.Philipsson, J.[Cattle breeds: Extinction or quasi-extant?]Cattle breeds: Extinction or quasi-extant?

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