Human chromosome (Chr) 18(HSA 18) contains approximately 85 million base pains of DNA. Thirty genes and pseudogenes have been mapped to HSA 18 by somatic cell genetics or in situ hybridization. Two bovine genes - Yamaguchi sacroma viral oncogene homology 1 (YESI) and desmocollin type 1 (DSC1) - h...
Agaba, Morris
,
Kemp, Stephen J.
,
Barendse, W.
,
Teale, A.J.
,
[Comparative mapping in cattle of genes located on human chromosome 18]
,
Comparative mapping in cattle of genes located on human chromosome 18
A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...
Nilsson, P.H.
,
Kang'a, S.
,
Rottengatter, K.
,
Suedbeck, U.
,
Iraqui, F.
,
Mwakaya, J.
,
Mwangi, D.
,
Womack, J.E.
,
Goldammer, T.
,
Schwerin, M.
,
Bradley, D.
,
Agaba, Morris
,
Sugimoto, K.
,
Gelhaus, A.
,
Horstmann, R.
,
Teale, A.J.
,
Kemp, Stephen J.
,
Hanotte, Olivier H.
,
[Radiation hybrid maps of candidate trypanotolerance regions in cattle]
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Radiation hybrid maps of candidate trypanotolerance regions in cattle
Background: The history of African indigenous cattle and their adaptation to environmental and human selection
pressure is at the root of their remarkable diversity. Characterization of this diversity is an essential step towards
understanding the genomic basis of productivity and adaptation to s...
High-through put technologies inevitably produce vast quantities of data. This presents challenges in terms of developing effective analysis methods, particularly where the analysis involves combining data derived from different experimental technologies. In this investigation, a systematic appro...
Rennie, C.
,
Hulme, H.
,
Fisher, P.
,
Halp, L.
,
Agaba, Morris
,
Noyes, H.A.
,
Kemp, Stephen J.
,
Brass, A.
,
[A systematic, data-driven approach to the combined analysis of microarray and QTL data]
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A systematic, data-driven approach to the combined analysis of microarray and QTL data
It is known that different breeds of cattle display differential susceptibilities to Trypanosome congolense infections, and that N'Dama cattle remain more productive after infection than Boran cattle which are more susceptible to T. congolense. Macrophages from both breeds were cultured in vitro ...
Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and...
Hanotte, Olivier H.
,
Ronin, Y.
,
Agaba, Morris
,
Nilsson, P.
,
Gelhaus, A.
,
Horstmann, R.
,
Sugimoto, Y.
,
Kemp, Stephen J.
,
Gibson, John P.
,
Korol, A.
,
Soller, M.
,
Teale, A.J.
,
[Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle]
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Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
Interspecies hybridization of bovids occurs between domestic cattle and at least three other species; American bison (Bison bison), yak (Bos grunniens) and banteng (Bos banteng). Birth of a cattle × buffalo (Bubalus bubalis) hybrid has reportedly occurred in Russia and in China, but these reports...
Hanotte, Olivier H.
,
Korol, A.
,
Agaba, Morris
,
Nilsson, P.
,
Gelhaus, P.
,
Horstmann, R.
,
Sugimoto, Y.
,
Kemp, Stephen J.
,
Soller, J.
,
Teale, A.J.
,
[Mapping of QTL controlling resistance to trypanosomosis in N'Dama X Boran cattle]
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Mapping of QTL controlling resistance to trypanosomosis in N'Dama X Boran cattle
Uniquely selected breeds bred over thousands of years of domestication in awide range of environments have been declared extinct over the last century. Still morebreeds are at risk of becoming extinct and the rate continues to accelerate. Assessing thecurrent status and possible future dynamics o...