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Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much more sensitiv...


Noyes, H.A.Agaba, MorrisAnderson, S.Archibald, A.L.Brass, A.Gibson, John P.Hall, L.Hulme, H.Oh, S.J.Kemp, Stephen J.[Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background]Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in bo...


Kemp, Stephen J.Hanotte, Olivier H.Agaba, MorrisNoyes, H.A.Gibson, John P.Archibald, A.L.Rennie, C.Hulme, H.Brass, A.[Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons]Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons

African animal trypanosomiasis (AAT) is endemic across Sub-Saharan African and is a major constraint to livestock production. The ability of certain cattle breeds to remain productive despite infection is known as trypanotolerance; however, the underlying immune mechanisms contributing to this tr...


Meade, K.G.O'Gorman, G.M.Hill, E.W.Narciandi, F.Agaba, MorrisKemp, Stephen J.O'Farrelly, C.O.MacHugh, D.E.[Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle]Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle

A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populati...


Teale, A.J.Agaba, MorrisClapcott, S.J.Gelhaus, A.Haley, C.Psifidis, A.Horstmann, R.Iraqui, F.Kemp, Stephen J.Nilsson, P.Schwerin, M.Sekikawa, K.Soller, M.Sugimoto, Y.Womack, J.[Resistance to trypanosomosis: Of markers, genes and mechanisms]Resistance to trypanosomosis: Of markers, genes and mechanisms
Barendse, W.Vaiman, D.Kemp, Stephen J.Sugimoto, Y.Armitage, S.M.Williams, J.L.Sun, H.S.Eggen, A.Agaba, MorrisAleyasin, S.A.Band, M.Bishop, M.D.Buitkamp, J.Byrne, K.Collins, F.Cooper, L.Coppettiers, W.Denys, B.Drinkwater, R.D.Easterday, K.Elduque, C.Ennis, S.Erhardt, G.Ferretti, L.Flavin, N.Gao, Q.Georges, M.Gurung, R.Harlizius, B.Hawkins, G.Hetzel, J.Hirano, T.Hulme, D.Jorgensen, C.Kessler, M.Kirkpatrick, B.W.Konfortov, B.Kostia, S.Kuhn, C.Lenstra, J.A.Leveziel, H.Lewin, H.A.Leyhe, B.Lil, L.Martin Burriel, I.McGraw, R.A.Miller, J.R.Moody, D.E.Moore, S.S.Nakane, S.Nijman, I.J.Olsaker, I.Pomp, D.Rando, A.Ron, M.Shalom, A.Teale, A.J.Thieven, U.Urquhart, B.G.D.Vage, D.I.Weghe, A. van deVarvio, S.Velmala, R.Vilkki, J.Weikard, R.Woodside, C.Womack, J.E.Zanotti, M.Zaragoza, P.[A medium-density genetic linkage map of the bovine genome]A medium-density genetic linkage map of the bovine genome
Nigussie, HelenMwacharo, Joram M.Osama, SarahAgaba, MorrisMekasha, YosephKebede, KefelegnAbegaz, SolomonPal, Sanjoy K.[Genetic diversity and matrilineal genetic origin of fat-rumped sheep in Ethiopia]Genetic diversity and matrilineal genetic origin of fat-rumped sheep in Ethiopia

Uniquely selected breeds bred over thousands of years of domestication in awide range of environments have been declared extinct over the last century. Still morebreeds are at risk of becoming extinct and the rate continues to accelerate. Assessing thecurrent status and possible future dynamics o...


Bett, R.C.Okeyo Mwai, AllyMalmfors, B.Johansson, K.Agaba, MorrisKugonza, D.R.Bhuiyan, A.K.F.H.Filho, A.E.V.Mariante, A.S.Mujibi, F.D.N.Philipsson, J.[Cattle breeds: Extinction or quasi-extant?]Cattle breeds: Extinction or quasi-extant?

We review the global dynamics of livestock disease over the last two decades. Our imperfect ability to detect and report disease hinders assessment of trends, but we suggest that, although endemic diseases continue their historic decline in wealthy countries, poor countries experience static or d...


Noyes, H.A.Brass, A.Obara, I.Anderson, S.I.Archibald, A.L.Bradley, D.G.Fisher, P.Freeman, A.R.Gibson, John P.Gicheru, M.Hall, L.Hanotte, Olivier H.Hulme, H.McKeever, Declan J.Murray, C.Oh, S.J.Tate, C.Smith, K.C.Tapio, M.Wambugu, J.Williams, D.Agaba, MorrisKemp, Stephen J.[Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection]Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection

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