A 69-kDa antigen of Trypanosoma congolense induces both IgM and IgG in experimentally infected cattle. Cloning and sequencing of the gene coding for this antigen revealed that it belongs to the heat shock protein 70 family (hsp70) and is homologous to mammalian immunoglobulin binding protein (BiP...
Boulange, A.F.
,
Katende, J.
,
Authié, E.
,
[A heat shock protein 70 of Trypanosoma congolense as a diagnositic antigen]
,
A heat shock protein 70 of Trypanosoma congolense as a diagnositic antigen
Trypanotolerance involves an ability to both control trypanosome multiplication and resist the pathogenic effects of trypanosome infection. Studies in the African Trypanotolerant Livestock Network and elsewhere have shown that the latter capacity is more closely correlated than the former to the ...
Infections of cattle with tsetse-transmitted Trypanosoma congolense are accompanied by antibody responses to the variable surface glycoprotein (VSG) and to two major invariant antigens, a member of the hsp 70 family and a 33KDa cysteine protease. During primary infection, trypanotolerant N'Dama (...
Lutje, V.
,
Authié, E.
,
Boulange, A.F.
,
Williams, D.J.L.
,
[Bovine T-cell responses to defined Trypanosoma congolense antigens during infection]
,
Bovine T-cell responses to defined Trypanosoma congolense antigens during infection
The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a parti...
Williams, D.J.L.
,
Taylor, K.
,
Newson, J.
,
Naessens, Jan
,
Authié, E.
,
[Protective and inappropriate antibody responses in trypanosome-infected cattle]
,
Protective and inappropriate antibody responses in trypanosome-infected cattle