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Blood samples were collected from parasitaemic cattle in the Ghibe Valley, Ethiopia, frozen in liquid nitrogen and transported to Nairobi, Kenya. Twelve of the stabilates were inoculated into individual Boran (Bos indicus) calves and characterised for their sensitivity, in turn, to diminazene ace...


Codjia, V.Mulatu, W.Majiwa, P.A.O.Leak, S.G.A.Rowlands, G.J.Authié, E.D'Ieteren, G.D.M.Peregrine, A.S.[Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium]Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of population of Trypanosoma congolense resistant to diminazene, isometamidium and homidium

Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the de...


Williams, D.J.L.Taylor, K.Wilkie, B.Gichuki, B.Authié, E.[Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle]Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle

Approximately 390 East African Zebu calves from birth to 3 years of age and their dams were monitored monthly from 1986 to 1992 in nine village herds in an area of high trypanosomiasis risk in southwest Ethiopia where there was resistance to all available trypanocidal drugs. Cattle were individua...


Rowlands, G.J.Mulatu, W.Authié, E.D'Ieteren, G.D.M.Leak, S.G.A.Nagda, S.M.[Effects of trypanosomiasis on growth and mortality of young East African Zebu cattle exposed to drug-resistant trypanosomes]Effects of trypanosomiasis on growth and mortality of young East African Zebu cattle exposed to drug-resistant trypanosomes

Trypanosomosis is one of the major constraints on animal production in areas of Africa which have the greatest potential for significant increases in domestic livestock populations and livestock productivity. While the eradication of trypanosomosis from the entire continent is an unrealistic goal...


D'Ieteren, G.D.M.Authié, E.Wissocq, N.M.Murray, M.[Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomiasis]Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomiasis
Maille, J.C.Authié, E.D'Ieteren, G.D.M.Leak, S.G.A.Maehl, J.H.H.Nagda, S.M.Rarieya, J.M.Rowlands, G.J.Sauveroche, B.Thorpe, W.R.Trail, J.C.M.Yangari, G.[Aspects of trypanotolerance and associations with growth rate in post-weaner N'Dama cattle under high trypanosomiasis risk]Aspects of trypanotolerance and associations with growth rate in post-weaner N'Dama cattle under high trypanosomiasis risk

Approximately 320 East African Zebu cows over 36 months of age were monitored monthly from 1986 to 1992 in nine village herds in an area of high trypanosomiasis risk in southwest Ethiopia where there was resistance to all available trypanocidal drugs. Cows were individually treated with diminazen...


Rowlands, G.J.Mulatu, W.Authié, E.D'Ieteren, G.D.M.Leak, S.G.A.Nagda, S.M.[Effects of trypanosomiasis on reproduction of East African Zebu cows exposed to drug-resistant trypanosomes]Effects of trypanosomiasis on reproduction of East African Zebu cows exposed to drug-resistant trypanosomes

Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...


Taylor, K.A.Lutje, V.Kennedy, D.Authié, E.Boulange, A.F.Logan-Henfrey, L.L.Gichuki, B.Gettinby, G.[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle

A comparison of T-cell-mediated immune responses in trypanotolerant N'Dama and susceptible Boran cattle during primary infection with tsetse-transmitted Trypanosoma congolense was conducted to assess whether different patterns of T-cell activation occurred during trypanosome infection. Proliferat...


Lutje, V.Taylor, K.A.Kennedy, D.Authié, E.Boulange, A.F.Gettinby, G.[Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection]Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection

African animal trypanosomosis (nagana) is arguably the most important parasitic disease affecting livestock in sub-Saharan Africa. Since none of the existing control measures are entirely satisfactory, vaccine development is being actively pursued. However, due to antigenic variation, the quest f...


Boulange, A.F.Khamadi, S.A.Pillay, D.Coetzer, T.H.T.Authié, E.[Production of congopain, the major cysteine protease of Trypanosoma (Nannomonas) congolense, in Pichia pastoris reveals unexpected dimerization at physiological Ph]Production of congopain, the major cysteine protease of Trypanosoma (Nannomonas) congolense, in Pichia pastoris reveals unexpected dimerization at physiological Ph

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