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Red Maasai and Dorper sheep were evaluated for their resistance to gastro-intestinal (GI) nematode parasites (predominantly Haemonchus contortus), productivity and productive efficiency (assessed on a metabolizable energy basis) in experiments undertaken at the Kenyan coast (sub-humid environment...


Baker, R.L.Mugambi, J.M.M.Audho, James O.Carles, A.B.Thorpe, W.R.[Genotype by environment interactions for productivity and resistance to gastro-intestinal nematode parasites in Red Maasai and Dorper sheep]Genotype by environment interactions for productivity and resistance to gastro-intestinal nematode parasites in Red Maasai and Dorper sheep

This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbr...


Menge, D.M.Behnke, J.M.Lowe, A.Gibson, John P.Iraqi, F.A.Baker, R.L.Wakelin, D.[Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice]Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsib...


Behnke, J.M.Iraqi, F.A.Menge, D.Baker, R.L.Gibson, John P.Wakelin, D.[Chasing the genes that control resistance to gastrointestinal nematodes]Chasing the genes that control resistance to gastrointestinal nematodes

Six first cross (F1) Red Maasai X Dorper rams were mated to both Red Maasai (R) and Dorper (D) ewes to produce 1342 double backcross progeny (672 3/4 D/1/4 R and 670 3/4 R/1/4 D lambs born alive). These six double backcross resource families are being used to identify quantitative trait loci con...


Mugambi, J.M.M.Audho, James O.Baker, R.L.[Evaluation of the phenotypic performance of a Red Maasai and Dorper double backcross resource population: Natural pasture challenge with gastro-intestinal nematode parasites]Evaluation of the phenotypic performance of a Red Maasai and Dorper double backcross resource population: Natural pasture challenge with gastro-intestinal nematode parasites

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...


Behnke, J.M.Mugambi, J.M.M.Clifford, S.Iraqi, F.A.Baker, R.L.Gibson, John P.Wakelin, D.[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project

This study quantifies comprehensively both within and between breed differences in resistance to natural infection with gastrointestinal parasites. This research programme was developed from an earlier study in coastal Kenya involving Dorper and Red Maasai X Dorper sheep. It is now part of an ILC...


Baker, R.L.Reynolds, L.Mwamachi, D.M.Audho, James O.Magadi, M.Miller, J.E.[Genetic resistance to gastrointestinal parasites in Dorper and Red Maasai X Dorper lambs in coastal Kenya]Genetic resistance to gastrointestinal parasites in Dorper and Red Maasai X Dorper lambs in coastal Kenya

Breeds of cattle, sheep and goats have been identified which are genetically resistant and/or tolerant to gastro-intestinal nematode parasites. Mapping and cloning of resistant genes will facilitate Development of new breeds of livestock, which combine this important disease resistance trait with...


Iraqi, F.A.Menge, D.Gibson, P.J.Baker, R.L.Wakelin, D.Behnke, J.M.Lowe, A.Teale, A.J.Wakelin, D.[Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice. Poster presentation]Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice. Poster presentation
Behnke, J.Iraqi, F.A.Menge, D.Lowe, A.Teale, A.J.Gibson, P.J.Baker, R.L.Wakelin, D.[Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice]Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice

Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...


Menge, D.M.Behnke, J.M.Iraqi, F.A.Lowe, A.Teale, A.J.Gibson, John P.Wakelin, D.Baker, R.L.[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice

This Report compares the efficacies of three anthelmintics, each belonging to one of the broad spectrum groups. It also identifies the genera of resistant worms through larval culture. The study was conducted on a commercial farm where anthelmintics had been used intensively. The results show cle...


Mwamachi, D.M.Audho, James O.Magadi, M.Reynolds, L.Baker, R.L.[Evidence for multiple anthelmintic resistance of gastrointestinal nematodes in sheep in coastal Kenya]Evidence for multiple anthelmintic resistance of gastrointestinal nematodes in sheep in coastal Kenya

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