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Recombinant bovine IFN gamma is a potent inhibitor of Cowdria ruminantium growth in vitro irrespective of the rickettsial stock, or the origin of the endothelial cells. These results suggest an important role for IFN gamma in protective immune responses against C. ruminantium infections. Here we ...


Totte, P.Vachiery, N.Martínez, D.Trap, I.Ballingall, K.T.MacHugh, Niall D.Bensaid, A.Werenne, J.[Recombinant bovine interferon gamma inhibits the growth of Cowdria ruminantium but fails to induce major histocompatibility complex class II following infection of endothelial cells]Recombinant bovine interferon gamma inhibits the growth of Cowdria ruminantium but fails to induce major histocompatibility complex class II following infection of endothelial cells

Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. Taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with...


Ballingall, K.T.Waibochi, L.Homes, E.C.Woelk, C.H.MacHugh, Niall D.Lutje, V.McKeever, Declan J.[The CD45 locus in cattle: Allelic polymorphism and evidence for exceptional positive natural selection]The CD45 locus in cattle: Allelic polymorphism and evidence for exceptional positive natural selection

We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative bovine endothelial cells, when cultured in the presence of supernatants derived from activated bovine T cells. We demonstrate the effecti...


Ballingall, K.T.Mwangi, D.M.MacHugh, Niall D.Taracha, E.L.N.Totte, P.McKeever, Declan J.[A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells]A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells

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