GI nematodes are most commonly controlled by chemotherapy. Anthelmintic efficacy is decreasing as drug resistance becomes widespread and other approaches are needed. Knowledge of protective immunity against GI parasites is important for the development of vaccine strategies. Success in this field...
Behnke, J.M.
,
Lowe, A.
,
Menge, M.
,
Iraqi, F.A.
,
Wakelin, D.
,
[Mapping genes for resistance to gastrointestinal nematodes]
,
Mapping genes for resistance to gastrointestinal nematodes
This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbr...
Menge, D.M.
,
Behnke, J.M.
,
Lowe, A.
,
Gibson, John P.
,
Iraqi, F.A.
,
Baker, R.L.
,
Wakelin, D.
,
[Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice]
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Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice
The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsib...
Behnke, J.M.
,
Iraqi, F.A.
,
Menge, D.
,
Baker, R.L.
,
Gibson, John P.
,
Wakelin, D.
,
[Chasing the genes that control resistance to gastrointestinal nematodes]
,
Chasing the genes that control resistance to gastrointestinal nematodes
A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens...
Behnke, J.M.
,
Menge, D.M.
,
Nagda, S.M.
,
Noyes, H.
,
Iraqi, F.A.
,
Kemp, Stephen J.
,
Mugambi, R.J.M.
,
Baker, R.L.
,
Wakelin, D.
,
Gibson, John P.
,
[Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice]
,
Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice
Fine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F6/F7 offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total wo...
Behnke, J.M.
,
Iraqi, F.A.
,
Mugambi, J.M.M.
,
Clifford, S.
,
Nagda, S.M.
,
Wakelin, D.
,
Kemp, Stephen J.
,
Leyden, B.
,
Gibson, John P.
,
[High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice]
,
High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice
Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...
Behnke, J.M.
,
Mugambi, J.M.M.
,
Clifford, S.
,
Iraqi, F.A.
,
Baker, R.L.
,
Gibson, John P.
,
Wakelin, D.
,
[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]
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Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project
Quantitative trait loci (QTL) associated with resistance to an intestinal worm in a well-defined murine model are described. These have been identified in an F(2) population derived from resistant (SWR) and susceptible (CBA) parental mouse strains infected with the gastro-intestinal nematode par...
Breeds of cattle, sheep and goats have been identified which are genetically resistant and/or tolerant to gastro-intestinal nematode parasites. Mapping and cloning of resistant genes will facilitate Development of new breeds of livestock, which combine this important disease resistance trait with...
Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...
Menge, D.M.
,
Behnke, J.M.
,
Iraqi, F.A.
,
Lowe, A.
,
Teale, A.J.
,
Gibson, John P.
,
Wakelin, D.
,
Baker, R.L.
,
[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]
,
Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice
Iraqi, F.A.
,
Menge, D.M.
,
Behnke, J.M.
,
Lowe, A.
,
Teale, A.J.
,
Gibson, John P.
,
Baker, L.R.
,
Wakelin, D.
,
[Detection of QTL for resistance to gastrointestinal nematode infection in mice. Abstract]
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Detection of QTL for resistance to gastrointestinal nematode infection in mice. Abstract