The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsib...
Behnke, J.M.
,
Iraqi, F.A.
,
Menge, D.
,
Baker, R.L.
,
Gibson, John P.
,
Wakelin, D.
,
[Chasing the genes that control resistance to gastrointestinal nematodes]
,
Chasing the genes that control resistance to gastrointestinal nematodes
Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...
Behnke, J.M.
,
Mugambi, J.M.M.
,
Clifford, S.
,
Iraqi, F.A.
,
Baker, R.L.
,
Gibson, John P.
,
Wakelin, D.
,
[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]
,
Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project
Quantitative trait loci (QTL) associated with resistance to an intestinal worm in a well-defined murine model are described. These have been identified in an F(2) population derived from resistant (SWR) and susceptible (CBA) parental mouse strains infected with the gastro-intestinal nematode par...