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Silatsa, Barberine A.Simo, GustaveGithaka, Naftaly W.Mwaura, StephenKamga, Rolin M.Oumarou, FariikouTiambo, Christian K.Bishop, Richard P.Djikeng, AppolinaireKuiate, Jules-RogerNjiokou, FlobertPelle, Roger[A comprehensive survey of the prevalence and spatial distribution of ticks infesting cattle in different agro-ecological zones of Cameroon]A comprehensive survey of the prevalence and spatial distribution of ticks infesting cattle in different agro-ecological zones of Cameroon

Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...


Pelle, RogerGraham, S.P.Njahira, Moses N.Osaso, J.Saya, R.M.Odongo, David O.Toye, Philip G.Spooner, P.R.Musoke, A.J.Mwangi, D.M.Taracha, E.L.N.Morrison, W. IvanWeir, W.Silva, J.Bishop, Richard P.[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity

African Cape buffalo (Syncerus caffer) is the wildlife reservoir of multiple species within the apicomplexan protozoan genus Theileria, including Theileria parva which causes East coast fever in cattle. A parasite, which has not yet been formally named, known as Theileria sp. (buffalo) has been r...


Bishop, Richard P.Hemmink, W.I.Morrison, J.D.Weir, W.Toye, Philip G.Sitt, T.Spooner, P.R.Musoke, A.J.Skilton, Robert A.Odongo, David O.[The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes]The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes

An improved Theileria parva DNA detection assay based on the polymerase chain reaction (PCR) using primers derived from the 104 kDa antigen (p104) gene was developed to detect parasite DNA in blood spots on filter paper. The specificity of the assay was validated using DNA from a wide range of ca...


Skilton, Robert A.Bishop, Richard P.Katende, J.M.Mwaura, S.Morzaria, S.P.[The persistence of Theileria parva infection in cattle immunised using two stocks which differ in their ability to induce a carrier state: Analysis using a novel blood spot PCR assay]The persistence of Theileria parva infection in cattle immunised using two stocks which differ in their ability to induce a carrier state: Analysis using a novel blood spot PCR assay

Tick-borne diseases (TBDs) are a major economic constraint to livestock production in sub-Saharan Africa. ILRI is focussing on developing a range of products, such as vaccines, diagnostics and decision support services to underpin improved control programmes against these diseases. We have develo...


Morzaria, S.P.Katende, J.Musoke, A.J.Nene, VishvanathSkilton, Robert A.Bishop, Richard P.[Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa]Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa

Recent advances in genomic technology have focused many veterinary researchers on the possibility of producing one multivalent recombinant vaccine against all the haemoparasites that infect cattle in the tropics. Before such a vaccine is developed it is essential to define target cattle popula...


Oura, C.A.L.Bishop, Richard P.Wampande, E.M.Lubega, G.W.Tait, A.[Application of a reverse line blot assay to the study of haemoparasites in cattle in Uganda]Application of a reverse line blot assay to the study of haemoparasites in cattle in Uganda
Bishop, Richard P.Sohanpal, B.K.Kariuki, D.Young, A.S.Nene, VishvanathBaylis, H.Allsopp, B.A.Spooner, P.R.Dolan, T.T.Morzaria, S.P.[Detection of a carrier state in Theileria parva infected cattle using the polymerase chain reaction]Detection of a carrier state in Theileria parva infected cattle using the polymerase chain reaction

A lambda gtll cDNA library was constructed using mRNA isolated from Theileria parva-infected bovine lymphocytes. Sequencing of random clones of this library resulted in the identification of a cDNA encoding bovine interleukin-16 (IL-16). The cDNA has an open reading frame of 1134 bp, and a 3? unt...


Mertens, B.Bishop, Richard P.Taracha, E.A.Morzaria, S.P.Nene, VishvanathSavadye, D.[Cloning, sequence and mRNA expression of bovine interleukin-16]Cloning, sequence and mRNA expression of bovine interleukin-16

The ‘Muguga cocktail’ live vaccine, delivered by an infection and treatment protocol, has been widely deployed in Eastern, Central and Southern Africa to protect cattle against East Coast fever, caused by Theileria parva. The vaccine contains 3 component stocks (Muguga, Serengeti-transformed and ...


Oura, C.A.L.Bishop, Richard P.Asiimwe, B.B.Spooner, P.R.Lubega, G.W.Tait, A.[Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field]Theileria parva live vaccination: parasite transmission, persistence and heterologous challenge in the field

The 'Muguga cocktail' which is composed of three Theileria parva stocks Muguga. Kiambu 5 and Serengeti-transformed has been used extensively for live vaccination against East Coast fever in cattle in eastern, central and southern Africa. Herein we describe the molecular characterization of the T....


Bishop, Richard P.Geysen, D.Spooner, P.R.Skilton, Robert A.Nene, VishvanathDolan, T.T.Morzaria, S.P.[Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle]Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle

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