Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs ...
Lambson, B.
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Nene, Vishvanath
,
Obura, M.
,
Shah, Tushaar
,
Pandit, P.
,
Ole-MoiYoi, O.K.
,
Delroux, K.
,
Welburn, S.C.
,
Skilton, Robert A.
,
Villiers, Etienne P. de
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Bishop, Richard P.
,
[Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells]
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Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells
The central variable region (CVR) within the B602L gene of the African swine fever virus (ASFV) is highly polymorphic within the 23 ASFV genotypes defined by sequencing of the C-terminal end of the p72 locus. Sequencing the p54 gene further discriminates ASFV genotypes that are conserved at the p...
Onzere, Cynthia K.
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Bastos, A.D.S.
,
Okoth, Edward A.
,
Lichoti, J.K.
,
Nyambego, Edwina B.
,
Owido, M.G.
,
Ndambuki, Gideon M.
,
Bronsvoort, B.M. de C.
,
Bishop, Richard P.
,
[Multi-locus sequence typing of African swine fever viruses from endemic regions of Kenya and Eastern Uganda (2011–2013) reveals rapid B602L central variable region evolution]
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Multi-locus sequence typing of African swine fever viruses from endemic regions of Kenya and Eastern Uganda (2011–2013) reveals rapid B602L central variable region evolution
Obara, I.
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Odongo, D.
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Kemp, Stephen J.
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Seitzer, U.
,
Bishop, Richard P.
,
[Relative fitness contribution of BoLA alleles in T.parva immune cattle: Interface with parasite genetic diversity]
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Relative fitness contribution of BoLA alleles in T.parva immune cattle: Interface with parasite genetic diversity
Molecules located on cell surfaces and those that are secreted from the cell frequently play a critical role in cell biology by mediating interaction with the external environment. These types of parasite molecules often constitute targets for protective host immune responses and are thus of addi...
Musembi, S.
,
Janoo, R.T.K.
,
Sohanpal, B.K.
,
Ochanda, H.
,
Ole-MoiYoi, O.K.
,
Bishop, Richard P.
,
Nene, Vishvanath
,
[Screening for Theileria parva secretory gene products by functional analysis in Saccharomyces cerevisiae]
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Screening for Theileria parva secretory gene products by functional analysis in Saccharomyces cerevisiae
Samples from infected domestic pigs associated with an outbreak of African swine fever (ASF) in three districts of central Uganda in 2007 were confirmed as being infected with African swine fever virus (ASFV) using a P72 gene-based polymerase chain reaction amplification (PCR) assay combined with...
Gallardo, C.
,
Ademun, A.R.
,
Nieto, R.
,
Nantima, Noelina
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Arias, Marisa
,
Martin, E.
,
Pelayo, V.
,
Bishop, Richard P.
,
[Genotyping of African swine fever virus (ASFV) isolates associated with disease outbreaks in Uganda in 2007]
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Genotyping of African swine fever virus (ASFV) isolates associated with disease outbreaks in Uganda in 2007
The primary goals of applying molecular tools, developed at ILRI in conjunction with the use of infection and treatment immunisation are quality control of vaccines; monitoring of possible vaccine breakthrough and breakdown; and assessment of the impact of introducing new parasite types on long-t...
Bishop, Richard P.
,
Nene, Vishvanath
,
Spooner, P.R.
,
Mbogo, S.
,
Kariuki, D.
,
Payne, R.
,
Morzaria, S.P.
,
[Application of molecular tools in support of deployment of Theileria parva live vaccines]
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Application of molecular tools in support of deployment of Theileria parva live vaccines
Bovine theileriosis caused by Theileria parva continues to be a major economic problem in many parts of Eastern, Southern, and Central Africa. Due to the unsustainable nature or the present control method-using toxic acaricides to kill ticks - alternative control methods are being sought. Live va...
Steinaa, Lucilla
,
Henson, Sonal P.
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Buus, Soren
,
Stryhn, Annette
,
Nielsen, Morten
,
Svitek, Nicholas
,
Onzere, Cynthia K.
,
Nyambego, Edwina B.
,
Ndambuki, Gideon M.
,
Bishop, Richard P.
,
[Sequencing swine leucocyte alleles for vaccine development]
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Sequencing swine leucocyte alleles for vaccine development