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We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...


Park, S.D.E.Adomefa, K.Dao, B.Hanotte, Olivier H.Kemp, Stephen J.Sow, R.S.Teale, A.J.Bradley, D.G.[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance

Cattle domestication and the complex histories of East Asian cattle breeds warrant further investigation. Through analysing the genomes of 49 modern breeds and eight East Asian ancient samples, worldwide cattle are consistently classified into five continental groups based on Y-chromosome haploty...


Ningbo ChenYudong CaiQiuming ChenRan LiKun WangYongzhen HuangSongmei HuShisheng HuangHucai ZhangZhuqing ZhengWeining SongZhijie MaYun MaRuihua DangZijing ZhangLei XuYutang JiaShanzhai LiuXiangpeng YueWeidong DengXiaoming ZhangZhouyong SunXianyong LanHan JianlinHong ChenBradley, D.G.Yu JiangChuzhao Lei[Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia]Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia

The past population dynamics of four domestic and one wild species of bovine were estimated using Bayesian skyline plots, a coalescent Markov chain Monte Carlo method that does not require an assumed parametric model of demographic history. Four domestic species share a recent rapid population ex...


Finlay, E.K.Gaillard, C.Vahidi, S.M.F.Mirhoseini, S.Z.Qi, X.B.El-Barody, M.A.A.Baird, J.F.Healy, B.C.Bradley, D.G.Han Jianlin[Bayesian inference of population expansions in domestic bovines]Bayesian inference of population expansions in domestic bovines

The chicken lysozyme gene encodes a hydrolase that has a key role in defence, especially in ovo. This gene was resequenced in global chicken populations [red, grey, Ceylon and green jungle fowl (JF)] and related bird species. Networks, summary statistics and tests of neutrality indicate that alth...


Downing, T.O'Farrelly, C.O.Bhuiyan, A.K.F.H.Silva, P.Naqvi, A.N.Sanfo, R.Sow, R.S.Overseas Development InstituteHanotte, Olivier H.Bradley, D.G.[Variation in chicken populations may affect the enzymatic activity of lysozyme]Variation in chicken populations may affect the enzymatic activity of lysozyme

There have been significant evolutionary pressures on the chicken during both its speciation and its subsequent domestication by man. Infectious diseases are expected to have exerted strong selective pressures during these processes. Consequently, it is likely that genes associated with disease s...


Downing, T.Lynn, D.J.Connell, S.Lloyd, A.T.Bhuiyan, A.K.F.H.Silva, P.Naqvi, A.N.Sanfo, R.Sow, R.S.Overseas Development InstituteO'Farrelly, C.O.Hanotte, Olivier H.Bradley, D.G.[Contrasting evolution of diversity at two disease-associated chicken genes]Contrasting evolution of diversity at two disease-associated chicken genes

Historical hybridization events between the two subspecies of cattle, Bos taurus and B. indicus, have occurred in several regions of the world, while other populations have remained nonadmixed. We typed closely linked X chromosome microsatellites in cattle populations with differing histories of ...


Freeman, A.R.Hoggart, C.J.Hanotte, Olivier H.Bradley, D.G.[Assessing the relative ages of admixture in the bovine hybrid zones of Africa and the Near East using X chromosome haplotype mosaicism]Assessing the relative ages of admixture in the bovine hybrid zones of Africa and the Near East using X chromosome haplotype mosaicism

Microsatellite markers are commonly used for population genetic analyses of livestock. However, up to now, combinations of microsatellite data sets or Microsatellite markers are commonly used for population genetic analyses of livestock. However, up to now, combinations of microsatellite data set...


Freeman, A.R.Bradley, D.G.Nagda, S.M.Gibson, John P.Hanotte, Olivier H.[Combination of multiple microsatellite data sets to investigate genetic diversity and admixture of domestic cattle]Combination of multiple microsatellite data sets to investigate genetic diversity and admixture of domestic cattle

We report for the first time, and for the whole of sub-Saharan Africa, the geographical distribution and the frequency of an indicine and a taurine Y specific allele amongst African cattle breeds. A total of 984 males from 69 indigenous African populations from 22 countries were analysed at the m...


Hanotte, Olivier H.Tawah, C.L.Bradley, D.G.Okomo, M.Verjee, Y.Ochieng, J.Rege, J.E.O.[Geographic distribution and frequency of a taurine B. Taurus and an indicine Bos indicus Y specific allele amongst sub-Saharan African cattle breeds]Geographic distribution and frequency of a taurine B. Taurus and an indicine Bos indicus Y specific allele amongst sub-Saharan African cattle breeds

We describe satellite DNA variation that detects hybridization of Bos indicus (Zebu or indicine cattle) and Bos taurus (taurine cattle) in African cattle populations. On southern blots hybridized to a satellite III probe, relative intensities of Hinf1 fragments correlated with the taurine-zebu co...


Nijman, I.J.Bradley, D.G.Hanotte, Olivier H.Otsen, M.Lenstra, J.A.[Satellite DNa polymorphisms and AFLP correlate with Bos indicus-taurus hybridization]Satellite DNa polymorphisms and AFLP correlate with Bos indicus-taurus hybridization

The genetic history of African cattle pastoralism is controversial and poorly understood. We reveal the genetic signatures of its origins, secondary movements, and differentiation through the study of 15 microsatellite loci in 50 indigenous cattle breeds spanning the present cattle distribution i...


Hanotte, Olivier H.Bradley, D.G.Ochieng, J.W.Verjee, Y.Hill, E.W.Rege, J.E.O.[African pastoralism: Genetic imprints of origins and migrations]African pastoralism: Genetic imprints of origins and migrations

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