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Cabrera, D.Gutiérrez, J.Cabello-Verrugio, C.Morales, M. G.Mezzano, S.Fadic, R.Casar, J. C.Hancke, J. L.Brandan, E.[Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis]Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis
Gutiérrez, J.Cabrera, D.Brandan, E.[Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells]Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells
Osses, N.Casar, J. C.Brandan, E.[Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism]Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism

Immobilization is a form of disuse characterized by a loss of strength and muscle mass. Among the main features are decreased IGF-1/Akt signalling and increased ubiquitin-proteasome pathway signalling, which induce greater myosin heavy chain degradation. Activation of the classical renin-angioten...


Morales, M.G.Abrigo, J.Acuna, M.J.Santos, R.A.Bader, M.Brandan, E.Simon, F.Olguin, H.Cabrera, D.Cabello-Verrugio, C.[Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas]Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate ...


Cabrera, D.Wree, A.Povero, D.Solís, N.Hernandez, A.Pizarro, M.Moshage, H.Torres, J.Feldstein, A.E.Cabello-Verrugio, C.Brandan, E.Barrera, F.Arab, J.P.Arrese, M.[Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis]Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis and eventually death from respiratory failure. Several studies indicate that skeletal muscle contributes to disease progression; however th...


Gonzalez, D.Contreras, O.Rebolledo, D.L.Espinoza, J.P.Van Zundert, B.Brandan, E.[ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers]ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

Background: Duchenne muscular dystrophy (DMD) is characterized by the absence of the cytoskeletal protein dystrophin, muscle wasting, increased transforming growth factor type beta (TGF-β) signaling, and fibrosis. At the present time, the only clinically validated treatments for DMD are glucocort...


Cabrera, D.Gutiérrez, J.Cabello-Verrugio, C.Morales, M. G.Mezzano, S.Fadic, R.Casar, J. C.Hancke, J. L.Brandan, E.[Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis]Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

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