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This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...


Kierstein, S.Noyes, H.Naessens, JanNakamura, Y.Pritchard, J.Gibson, John P.Kemp, Stephen J.Brass, A.[Gene expression profiling in a mouse model for African trypanosomiasis]Gene expression profiling in a mouse model for African trypanosomiasis

African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in t...


Goodhead, I.Archibald, A.L.Amwayi, P.Brass, A.Gibson, John P.Hall, N.Hughes, Monica A.Limo, M.K.H.Iraqi, F.A.Kemp, Stephen J.Noyes, H.A.[A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice]A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice

It is increasingly common to combine Microarray and Quantitative Trait Loci data to aid the search for candidate genes responsible for phenotypic variation. Workflows provide a means of systematically processing these large datasets and also represent a framework for the re-use and the explicit d...


Fisher, P.Hedeler, C.Wolstencroft, K.Hulme, H.Noyes, H.Kemp, Stephen J.Stevens, R.Brass, A.[A systematic strategy for large-scale analysis of genotype-phenotype correlations: identification of candidate genes involved in African trypanosomiasis]A systematic strategy for large-scale analysis of genotype-phenotype correlations: identification of candidate genes involved in African trypanosomiasis

C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are dif...


Hassan, M.Agaba, MorrisBulimo, WallaceNoyes, H.Brass, A.Hinsley, T.Iraqi, F.A.Kemp, Stephen J.[Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis]Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis
Alimohammadian, M.H.Anderson, S.Brass, A.Gibson, John P.Hulme, H.Iraqi, F.A.Kemp, Stephen J.Agaba, MorrisNaessens, JanNoyes, H.A.[Identification of gene networks associated with anaemia caused by Trypanosoma congolense]Identification of gene networks associated with anaemia caused by Trypanosoma congolense

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