Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample fr...
Cook, Elizabeth A.J.
,
Grossi-Soyster, E.N.
,
Glanville, William A. de
,
Thomas, L.F.
,
Kariuki, S.
,
Bronsvoort, B.M. de C.
,
Wamae, C.N.
,
LaBeaud, A.D.
,
Fèvre, Eric M.
,
[The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya]
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The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya
The major histocompatibility complex (MHC) region contains many genes that are key regulators of both innate and adaptive immunity including the polymorphic MHCI and MHCII genes. Consequently, the characterisation of the repertoire of MHC genes is critical to understanding the variation that dete...
Vasoya, D.
,
Law, A.
,
Motta, P.
,
Mingyan Yu
,
Muwonge, A.
,
Cook, Elizabeth A.J.
,
Xiaoying Li
,
Bryson, K.
,
MacCallam, A.
,
Sitt, T.
,
Toye, Philip G.
,
Bronsvoort, B.M. de C.
,
Watson, Mick
,
Morrison, W. Ivan
,
Connelley, T.
,
[Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing]
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Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing
Most studies of infectious diseases in East African cattle have concentrated on gastro-intestinal parasites and vector-borne diseases. As a result, relatively little is known about viral diseases, except for those that are clinically symptomatic or which affect international trade such as foot an...
Callaby, R.
,
Toye, Philip G.
,
Jennings, A.
,
Thumbi, S.M.
,
Wyk, I.C. van
,
Hanotte, Olivier H.
,
Mbole-Kariuki, Mary N.
,
Bronsvoort, B.M. de C.
,
Kruuk, L.E.B.
,
Woolhouse, Mark E.J.
,
Kiara, Henry K.
,
[Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya]
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Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya
Scolamacchia, F.
,
Handel, I.G.
,
Fèvre, Eric M.
,
Morgan, K.L.
,
Tanya, V.N.
,
Bronsvoort, B.M. de C.
,
[Serological patterns of brucellosis, leptospirosis and Q fever in Bos indicus cattle in Cameroon]
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Serological patterns of brucellosis, leptospirosis and Q fever in Bos indicus cattle in Cameroon
The Kenyan East African zebu cattle are valuable and widely used genetic resources. Previous studies using microsatellite loci revealed the complex history of these populations with the presence of taurine and zebu genetic backgrounds. Here, we estimate at genome-wide level the genetic compositio...
Mbole-Kariuki, Mary N.
,
Sonstegard, T.S.
,
Orth, Alan
,
Thumbi, S.M.
,
Bronsvoort, B.M. de C.
,
Kiara, Henry K.
,
Toye, Philip G.
,
Conradie, I.
,
Jennings, A.
,
Coetzer, K.
,
Woolhouse, Mark E.J.
,
Hanotte, Olivier H.
,
Tapio, M.
,
[Genome-wide analysis reveals the ancient and recent admixture history of East African Shorthorn Zebu from Western Kenya]
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Genome-wide analysis reveals the ancient and recent admixture history of East African Shorthorn Zebu from Western Kenya
In natural populations, individuals may be infected with multiple distinct pathogens at a time. These pathogens may act independently or interact with each other and the host through various mechanisms, with resultant varying outcomes on host health and survival. To study effects of pathogens and...
Thumbi, S.M.
,
Bronsvoort, B.M. de C.
,
Poole, Elizabeth J.
,
Kiara, Henry K.
,
Toye, Philip G.
,
Mbole-Kariuki, Mary N.
,
Conradie, I.
,
Jennings, A.
,
Handel, I.G.
,
Coetzer, J.A.W.
,
Steyl, J.C.A.
,
Hanotte, Olivier H.
,
Woolhouse, Mark E.J.
,
[Parasite co-infections and their impact on survival of indigenous cattle]
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Parasite co-infections and their impact on survival of indigenous cattle
The presence of bluetongue virus (BTV) and Epizootic Haemorrhagic Disease virus (EHDV) in indigenous calves in western Kenya was investigated. Serum was analysed for BTV and EHDV antibodies. The population seroprevalences for BTV and EHDV for calves at 51 weeks of age were estimated to be 0.942 (...
Toye, Philip G.
,
Batten, C.A.
,
Kiara, Henry K.
,
Henstock, M.R.
,
Edwards, L.
,
Thumbi, S.M.
,
Poole, Elizabeth J.
,
Handel, I.G.
,
Bronsvoort, B.M. de C.
,
Hanotte, Olivier H.
,
Coetzer, J.A.W.
,
Woolhouse, Mark E.J.
,
Oura, C.A.L.
,
[Bluetongue and epizootic haemorrhagic disease virus in local breeds of cattle in Kenya]
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Bluetongue and epizootic haemorrhagic disease virus in local breeds of cattle in Kenya
The passive transfer of antibodies from dams to offspring via colostrum is believed to play an important role in protecting neonatal mammals from infectious disease. The study presented here investigates the uptake of colostrum by 548 calves in western Kenya maintained under smallholder farming, ...
Toye, Philip G.
,
Handel, I.
,
Gray, J.
,
Kiara, Henry K.
,
Thumbi, S.M.
,
Jennings, A.
,
Wyk, I.C. van
,
Ndila, M.
,
Hanotte, Olivier H.
,
Coetzer, K.
,
Woolhouse, Mark E.J.
,
Bronsvoort, B.M. de C.
,
[Maternal antibody uptake, duration and influence on survival and growth rate in a cohort of indigenous calves in a smallholder farming system in western Kenya]
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Maternal antibody uptake, duration and influence on survival and growth rate in a cohort of indigenous calves in a smallholder farming system in western Kenya
The accurate estimation of livestock weights is important for many aspects of livestock management including nutrition, production and appropriate dosing of pharmaceuticals. Subtherapeutic dosing has been shown to accelerate pathogen resistance which can have subsequent widespread impacts. There ...
Lesosky, M.
,
Dumas, S.
,
Conradie, I.
,
Handel, I.G.
,
Jennings, A.
,
Thumbi, S.M.
,
Toye, Philip G.
,
Bronsvoort, B.M. de C.
,
[A live weight-heart girth relationship for accurate dosing of east African shorthorn zebu cattle]
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A live weight-heart girth relationship for accurate dosing of east African shorthorn zebu cattle
The development of sensitive surveillance technologies using PCR-based detection of microbial DNA, such as the reverse line blot assay, can facilitate the gathering of epidemiological information on tick-borne diseases, which continue to hamper the productivity of livestock in many parts of Afric...
Njiiri, N.E.
,
Bronsvoort, B.M. de C.
,
Collins, N.E.
,
Steyn, H.C.
,
Troskie, M.
,
Vorster, I.
,
Mwangi, T.S.
,
Sibeko, K.P.
,
Jennings, A.
,
Wyk, I.C. van
,
Mbole-Kariuki, Mary N.
,
Kiara, Henry K.
,
Poole, Elizabeth J.
,
Hanotte, Olivier H.
,
Coetzer, K.
,
Oosthuizen, M.C.
,
Woolhouse, Mark E.J.
,
Toye, Philip G.
,
[The epidemiology of tick-borne haemoparasites as determined by the reverse line blot hybridization assay in an intensively studied cohort of calves in western Kenya]
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The epidemiology of tick-borne haemoparasites as determined by the reverse line blot hybridization assay in an intensively studied cohort of calves in western Kenya