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Cabrera, D.Gutiérrez, J.Cabello-Verrugio, C.Morales, M. G.Mezzano, S.Fadic, R.Casar, J. C.Hancke, J. L.Brandan, E.[Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis]Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

Background: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile ...


Cabrera, D.Cabello-Verrugio, C.Solís, N.Martín, D.S.Cofré, C.Pizarro, M.Arab, J.P.Abrigo, J.Campos, F.Irigoyen, B.Carrasco-Avino, G.Bezares, K.Riquelme, V.Riquelme, A.Arrese, M.Barrera, F.[Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation]Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation

Duchene Muscular Dystrophy (DMD) is the most frequent muscular dystrophy and one of the most severe due to the absence of the dystrophin protein. Typical pathological features include muscle weakness, muscle wasting, degeneration, and inflammation. At advanced stages DMD muscles present exacerbat...


Cordova, G.Negroni, E.Cabello-Verrugio, C.Mouly, V.Trollet, C.[Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy]Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy

Immobilization is a form of disuse characterized by a loss of strength and muscle mass. Among the main features are decreased IGF-1/Akt signalling and increased ubiquitin-proteasome pathway signalling, which induce greater myosin heavy chain degradation. Activation of the classical renin-angioten...


Morales, M.G.Abrigo, J.Acuna, M.J.Santos, R.A.Bader, M.Brandan, E.Simon, F.Olguin, H.Cabrera, D.Cabello-Verrugio, C.[Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas]Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate ...


Cabrera, D.Wree, A.Povero, D.Solís, N.Hernandez, A.Pizarro, M.Moshage, H.Torres, J.Feldstein, A.E.Cabello-Verrugio, C.Brandan, E.Barrera, F.Arab, J.P.Arrese, M.[Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis]Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Angiotensin (1–7) (Ang-(1–7)) is a bioactive heptapeptide with a short half-life and has beneficial effects in several tissues – among them, skeletal muscle – by preventing muscle atrophy. Dendrimers are promising vehicles for the protection and transport of numerous bioactive molecules. This wor...


Márquez-Miranda, V.Abrigo, J.Rivera, J.C.Araya-Durán, I.Aravena, J.Simon, F.Pacheco, N.González-Nilo, F.D.Cabello-Verrugio, C.[The complex of PAMAM-OH dendrimer with Angiotensin (1–7) prevented the disuse-induced skeletal muscle atrophy in mice]The complex of PAMAM-OH dendrimer with Angiotensin (1–7) prevented the disuse-induced skeletal muscle atrophy in mice

Cabello-Verrugio, C.Vilos, C.Rodrigues-Diez, R.Estrada, L.[Oxidative stress in disease and aging: Mechanisms and therapies 2018]Oxidative stress in disease and aging: Mechanisms and therapies 2018

Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experiment...


Haensgen, H.Albornoz, E.Opazo, M.C.Bugueño, K.Jara Fernández, E.L.Binzberger, R.Rivero-Castillo, T.Venegas Salas, L.F.Simon, F.Cabello-Verrugio, C.Elorza, A.A.Kalergis, A.M.Bueno, S.M.Riedel, C.A.[Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis]Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis

Background: Duchenne muscular dystrophy (DMD) is characterized by the absence of the cytoskeletal protein dystrophin, muscle wasting, increased transforming growth factor type beta (TGF-β) signaling, and fibrosis. At the present time, the only clinically validated treatments for DMD are glucocort...


Cabrera, D.Gutiérrez, J.Cabello-Verrugio, C.Morales, M. G.Mezzano, S.Fadic, R.Casar, J. C.Hancke, J. L.Brandan, E.[Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis]Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

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