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Duchene Muscular Dystrophy (DMD) is the most frequent muscular dystrophy and one of the most severe due to the absence of the dystrophin protein. Typical pathological features include muscle weakness, muscle wasting, degeneration, and inflammation. At advanced stages DMD muscles present exacerbat...


Cordova, G.Negroni, E.Cabello-Verrugio, C.Mouly, V.Trollet, C.[Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy]Combined therapies for Duchenne muscular dystrophy to optimize treatment efficacy

Background: Duchenne muscular dystrophy (DMD) is characterized by the absence of the cytoskeletal protein dystrophin, muscle wasting, increased transforming growth factor type beta (TGF-β) signaling, and fibrosis. At the present time, the only clinically validated treatments for DMD are glucocort...


Cabrera, D.Gutiérrez, J.Cabello-Verrugio, C.Morales, M. G.Mezzano, S.Fadic, R.Casar, J. C.Hancke, J. L.Brandan, E.[Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis]Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis

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