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Background: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile ...


Cabrera, D.Cabello-Verrugio, C.Solís, N.Martín, D.S.Cofré, C.Pizarro, M.Arab, J.P.Abrigo, J.Campos, F.Irigoyen, B.Carrasco-Avino, G.Bezares, K.Riquelme, V.Riquelme, A.Arrese, M.Barrera, F.[Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation]Somatotropic axis dysfunction in non-alcoholic fatty liver disease: Beneficial hepatic and systemic effects of hormone supplementation

Immobilization is a form of disuse characterized by a loss of strength and muscle mass. Among the main features are decreased IGF-1/Akt signalling and increased ubiquitin-proteasome pathway signalling, which induce greater myosin heavy chain degradation. Activation of the classical renin-angioten...


Morales, M.G.Abrigo, J.Acuna, M.J.Santos, R.A.Bader, M.Brandan, E.Simon, F.Olguin, H.Cabrera, D.Cabello-Verrugio, C.[Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas]Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate ...


Cabrera, D.Wree, A.Povero, D.Solís, N.Hernandez, A.Pizarro, M.Moshage, H.Torres, J.Feldstein, A.E.Cabello-Verrugio, C.Brandan, E.Barrera, F.Arab, J.P.Arrese, M.[Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis]Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

This research presents a proposal of malware classification and its update based on capacity and obfuscation. This article is an extension of [4]a, and describes the procedure for malware updating, that is, to take obsolete malware that is already detectable by antiviruses, update it through obfu...


Barría, C.Cordero, D.Cubillos, C.Palma, M.Cabrera, D.[Obfuscation-based malware update: A comparison of manual and automated methods]Obfuscation-based malware update: A comparison of manual and automated methods

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