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Schwartz, J.C.Hemmink, J.D.Graham, S.P.Tchilian, E.Charleston, B.Hammer, S.E.Ho, C.S.Hammond, J.A.[The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine]The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine

Theileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2-3 weeks of infection. Analyses of the cellular response in the lymph node draining the site of infection demonstrated an early T cell response, with the appearance of ...


Houston, E.F.Taracha, E.L.N.Brackenbury, L.MacHugh, Niall D.McKeever, Declan J.Charleston, B.Morrison, W. Ivan[Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function]Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function

Rift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula. No licensed vaccines are currently available for humans and those widely used in livestock have major safety concerns. A ‘One Health’ vaccine develo...


Warimwe, G.M.Gesharisha, J.Carr, B.V.Otieno, S.Otingah, K.Wright, D.Charleston, B.Okoth, Edward A.Elena, L.G.Lorenzo, G.Ayman, E.B.Alharbi, N.K.Al-Dubaib, M.A.Brun, A.Gilbert, S.C.Nene, VishvanathHill, A.V.S.[Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever]Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever

We assessed research knowledge gaps in the fields of FMDV (foot-and-mouth disease virus) pathogenesis and molecular biology by performing a literature review (2011–15) and collecting research updates (2014) from 33 institutes from across the world. Findings were used to identify priority areas fo...


Robinson, L.Knight-Jones, T.J.D.Charleston, B.Rodríguez, L.L.Gay, C.G.Sumption, K.J.Vosloo, W.[Global foot-and-mouth disease research update and gap analysis: 7 – Pathogenesis and molecular biology]Global foot-and-mouth disease research update and gap analysis: 7 – Pathogenesis and molecular biology

This study assessed gaps and priorities for FMDV (foot-and-mouth disease virus) research in the field of immunology. The study took the form of a literature review (2011-15) combined with research updates collected in 2014 from 33 institutes from across the world. Findings were used to identify p...


Robinson, L.Knight-Jones, T.J.D.Charleston, B.Rodríguez, L.L.Gay, C.G.Sumption, K.J.Vosloo, W.[Global foot-and-mouth disease research update and gap analysis: 6 – Immunology]Global foot-and-mouth disease research update and gap analysis: 6 – Immunology

The Global Foot-and-mouth disease (FMD) Research Alliance periodically reviews the state of FMD research to assess progress and to identify new priorities. In this supplement we provide an update of global FMD research, comprising (i) this overview paper, which includes background information wit...


Knight-Jones, T.J.D.Robinson, L.Charleston, B.Rodríguez, L.L.Gay, C.G.Sumption, K.J.Vosloo, W.[Global foot-and-mouth disease research update and gap analysis: 1 – Overview of global status and research needs]Global foot-and-mouth disease research update and gap analysis: 1 – Overview of global status and research needs

We assessed knowledge gaps in foot-and-mouth disease (FMD) research. Findings are reported in a series of papers, and in this article, we consider biotherapeutics and disinfectants. The study took the form of a literature review (2011–2015) combined with research updates collected in 2014 from 33...


Robinson, L.Knight-Jones, T.J.D.Charleston, B.Rodríguez, L.L.Gay, C.G.Sumption, K.J.Vosloo, W.[Global foot-and-mouth disease research update and gap analysis: 5 – Biotherapeutics and disinfectants]Global foot-and-mouth disease research update and gap analysis: 5 – Biotherapeutics and disinfectants

This study assessed research knowledge gaps in the field of FMDV (foot-and-mouth disease virus) vaccines. The study took the form of a literature review (2011–15) combined with research updates collected in 2014 from 33 institutes from across the world. Findings were used to identify priority are...


Robinson, L.Knight-Jones, T.J.D.Charleston, B.Rodríguez, L.L.Gay, C.G.Sumption, K.J.Vosloo, W.[Global foot-and-mouth disease research update and gap analysis: 3 – Vaccines]Global foot-and-mouth disease research update and gap analysis: 3 – Vaccines

We assessed knowledge gaps in foot-and-mouth disease (FMD) research, and in this study, we consider (i) epidemiology, (ii) wildlife and (iii) economics. The study took the form of a literature review (2011–2015) combined with research updates collected in 2014 from 33 institutes from across the w...


Knight-Jones, T.J.D.Robinson, L.Charleston, B.Rodríguez, L.L.Gay, C.G.Sumption, K.J.Vosloo, W.[Global foot-and-mouth disease research update and gap analysis: 2 – Epidemiology, wildlife and economics]Global foot-and-mouth disease research update and gap analysis: 2 – Epidemiology, wildlife and economics

This study assessed knowledge gaps in foot-and-mouth disease (FMD) research in the field of diagnostics. The study took the form of a literature review (2011–15) combined with research updates collected in 2014 from 33 institutes from around the world. Findings were used to identify priority area...


Knight-Jones, T.J.D.Robinson, L.Charleston, B.Rodríguez, L.L.Gay, C.G.Sumption, K.J.Vosloo, W.[Global foot-and-mouth disease research update and gap analysis: 4 – Diagnostics]Global foot-and-mouth disease research update and gap analysis: 4 – Diagnostics

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