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Extracorporeal membrane oxygenation (ECMO) is increasingly being used to treat severe acute respiratory distress syndrome (ARDS). However, there is limited clinical evidence about how to optimize the technique. Experimental research can provide an alternative to fill the actual knowledge gap. The...


Araos, JoaquínAlegría, LeylaGarcía, PatricioDamiani, FelipeTapia, PabloSoto, DagobertoSalomon, TatianaRodriguez, FelipeAmthauer, MacarenaErranz, BenjamínCastro, GabrielCarreño, PamelaMedina, TaniaRetamal, JaimeCruces, PabloBugedo, GuillermoBruhn, Alejandro[Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome]Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome

Background Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim...

Introducción Test dinámicos de precarga, variación de presión de pulso (PPV) y variación de volumen sistólico (SVV) han emergido como herramientas poderosas para predecir respuesta a la administración de fluidos. Actualmente la influencia de factores distintos a la precarga en la determinación d...


Erranz, BenjamínDíaz, FrancoDonoso, AlejandroSalomón, TatianaCarvajal, CristóbalTorres, María FernandaCruces, Pablo[Una compliance pulmonar disminuida incrementa los test dinámicos de precarga en un modelo pediátrico de lesión pulmonar aguda][Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model]Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model

Abstract Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it...


Cruces, PabloRetamal Montes, JaimeHurtado Sepúlveda, DanielErranz, BenjamínIturrieta, PabloGonzález, CarlosDíaz, Franco[A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection]A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Abstract Background Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs without MV support, the me...


Hurtado Sepúlveda, DanielSarabia Vallejos, MauricioIturrieta, PabloErranz, BenjamínLillo, FelipeMorales, FelipeBlaha, KatherineMedina, TaniaDiaz, FrancoCruces, Pablo[Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation]Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation

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