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Abstract Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it...


Cruces, PabloRetamal Montes, JaimeHurtado Sepúlveda, DanielErranz, BenjamínIturrieta, PabloGonzález, CarlosDíaz, Franco[A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection]A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Abstract Background Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs without MV support, the me...


Hurtado Sepúlveda, DanielSarabia Vallejos, MauricioIturrieta, PabloErranz, BenjamínLillo, FelipeMorales, FelipeBlaha, KatherineMedina, TaniaDiaz, FrancoCruces, Pablo[Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation]Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation

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