Background
Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa. We hypothesized that a vaccine targeting tick proteins that are involved in attachment and feeding might affect...
Olds, Cassandra L.
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Mwaura, S.
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Odongo, David O.
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Scoles, Glen A.
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Bishop, R.
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Daubenberger, C.A.
,
[Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission]
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Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission
Vaccines based on recombinant Bm86 gut antigen from Boophilus microplus are a useful component of integrated control strategies against B. microplus infestations of cattle. The capacity of such vaccines to control heterologous infestations by two African tick species was investigated. The mean we...
Odongo, D.
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Kamau, L.
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Skilton, Robert A.
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Mwaura, S.
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Nitsch, C.
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Musoke, A.J.
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Taracha, E.A.
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Daubenberger, C.A.
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Bishop, Richard P.
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[Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus]
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Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus
T cells bearing the gamma delta antigen receptor (gamma delta T cells) can constitute up to 50 percent of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gamma delta T cells are involved in immune responses against Theileria parva. Gamma delta T c...
Daubenberger, C.A.
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Taracha, E.L.N.
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Gaidulis, L.
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Davis, W.C.
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McKeever, Declan J.
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[Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva]
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Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva
Odongo, D.
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Olds, Cassandra L.
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Daubenberger, C.A.
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Musoke, A.J.
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Scoles, Glen A.
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Knowles, D.
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Bishop, Richard P.
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[Immunological control of ticks: Research towards development of an anti-tick vaccine for cattle]
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Immunological control of ticks: Research towards development of an anti-tick vaccine for cattle
Rothen, J.
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Bishop, Richard P.
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Mwaura, S.
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Pfluger, V.
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Daubenberger, C.A.
,
Olds, Cassandra L.
,
[Mapping distributions of ticks and tick-borne diseases in Africa: Effects of climate change and the implications for human and animal health]
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Mapping distributions of ticks and tick-borne diseases in Africa: Effects of climate change and the implications for human and animal health
The BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with...
Kopp, N.
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Díaz, D.
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Amacker, M.
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Odongo, David O.
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Beier, K.
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Nitsch, C.
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Bishop, Richard P.
,
Daubenberger, C.A.
,
[Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues]
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Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues
Nandam, D.
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Daubenberger, C.A.
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Mpimbaza, G.W.N.
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Pearson, T.W.
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[A rapid, single step purification method for immunogenic members of the hsp 70 family. Validation and application]
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A rapid, single step purification method for immunogenic members of the hsp 70 family. Validation and application
There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, ...
Norling, M.
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Bishop, Richard P.
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Pelle, Roger
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Weihong Qi
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Henson, S.
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Drábek, E.F.
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Tretina, K.
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Odongo, D.
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Mwaura, S.
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Njoroge, T.
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Bongcam-Rudloff, E.
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Daubenberger, C.A.
,
Silva, J.C.
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[The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence]
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The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence
T cells bearing the gamma-delta antigen can constitute up to 50% of T cells in peripheral blood and lymphoid organs of calves below six months of age. This observation prompted us to investigate the involvement of gamma-delta T cells in the immune response of yound calves against Theileria parva.
Theileria parva, a tick-transmitted protozoan parasite, infects cattle in eastern, central and southern Africa, leading to an acute, usually fatal lymphoproliferative disorder known as East Coast fever (1). It has been shown that the protective immune response against T. parva is mediated by clas...
Daubenberger, C.A.
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Heussler, V.
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Gobright, E.I.
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Wijngaard, P.L.J.
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Clevers, H.C.
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Wells, C.
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Tsuji, N.
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Musoke, A.J.
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McKeever, Declan J.
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[Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan parasite Theileria parva]
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Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan parasite Theileria parva