T cells bearing the gamma delta antigen receptor (gamma delta T cells) can constitute up to 50 percent of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gamma delta T cells are involved in immune responses against Theileria parva. Gamma delta T c...
Daubenberger, C.A.
,
Taracha, E.L.N.
,
Gaidulis, L.
,
Davis, W.C.
,
McKeever, Declan J.
,
[Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva]
,
Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva
T cells bearing the gamma-delta antigen can constitute up to 50% of T cells in peripheral blood and lymphoid organs of calves below six months of age. This observation prompted us to investigate the involvement of gamma-delta T cells in the immune response of yound calves against Theileria parva.
Theileria parva, a tick-transmitted protozoan parasite, infects cattle in eastern, central and southern Africa, leading to an acute, usually fatal lymphoproliferative disorder known as East Coast fever (1). It has been shown that the protective immune response against T. parva is mediated by clas...
Daubenberger, C.A.
,
Heussler, V.
,
Gobright, E.I.
,
Wijngaard, P.L.J.
,
Clevers, H.C.
,
Wells, C.
,
Tsuji, N.
,
Musoke, A.J.
,
McKeever, Declan J.
,
[Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan parasite Theileria parva]
,
Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan parasite Theileria parva
A flow cytometric method using anti-parasite antibodies was developed to measure binding of theileria parva sporozoites to the target bovine lymphocyte membrane. Parasite-host cell interactions could be inhibited by monoclonal antibodies to bovine MHC class I and partially by one of two antibodie...
Syfrig, J.
,
Wells, C.
,
Daubenberger, C.A.
,
Musoke, A.J.
,
Naessens, Jan
,
[Proteolytic cleavage of surface proteins enhances susceptibility of lymphocytes to invasion by Theileria parva sporozoites]
,
Proteolytic cleavage of surface proteins enhances susceptibility of lymphocytes to invasion by Theileria parva sporozoites