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Book Chapter 2017

A Fosmid pool-based next generation sequencing approach to haplotype-resolve whole genomes

Autor: Suk, Eun-Kyung Schulz, Sabrina Mentrup, Birgit Huebsch, Thomas Duitama, Jorge Hoehe, Margret R.

Haplotype resolution of human genomes is essential to describe and interpret genetic variation and its impact on biology and disease. Our approach to haplotyping relies on converting genomic DNA into a fosmid library, which represents the entire diploid genome as a collection of haploid DNA clone...

Enlace original: https://cgspace.cgiar.org/handle/10568/79937

Investigación en Agricultura

GENETIC RESOURCES

GENETIC VARIATION

HAPLOTYPING

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Suk, Eun-Kyung , Schulz, Sabrina , Mentrup, Birgit , Huebsch, Thomas , Duitama, Jorge , Hoehe, Margret R. , [A Fosmid pool-based next generation sequencing approach to haplotype-resolve whole genomes] , A Fosmid pool-based next generation sequencing approach to haplotype-resolve whole genomes

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Genomic variants detection and genotyping

A Fosmid pool-based next generation sequencing approach to haplotype-resolve whole genomes