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Journal Article 2017-06-27

Autor: Mariner, Jeffrey C. Gachanja, J. Tindih, H.S. Toye, Philip G.

The research objective was to develop a thermostable vaccine against peste des petits ruminants (PPR), a morbilliviral disease of small ruminants targeted for eradication that is a major constraint on the livelihoods of the rural poor throughout much of Africa and Asia. Although existing PPR vacc...

Enlace original: https://cgspace.cgiar.org/handle/10568/81517

Investigación en Agricultura
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Mariner, Jeffrey C. ,  Gachanja, J. ,  Tindih, H.S. ,  Toye, Philip G. ,  [A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia] ,  A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia
Journal Article 2000-06-15

Autor: Skilton, Robert A. Musoke, A.J. Wells, C.W. Yagi, Y. Nene, Vishvanath Spooner, P.R. Gachanja, J. Osaso, J. Bishop, Richard P. Morzaria, S.P.

Previous studies using monoclonal antibody (mAb) 4C9 specific for a 32 kDa antigen (p32) of Theileria parva demonstrated expression of the antigen on the surface of the sporozoite, making it a potential antigen for sporozoite neutralization. A full-length cDNA encoding the major merozoite/piropla...

Enlace original: https://cgspace.cgiar.org/handle/10568/35036

Investigación en Agricultura
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Skilton, Robert A. ,  Musoke, A.J. ,  Wells, C.W. ,  Yagi, Y. ,  Nene, Vishvanath ,  Spooner, P.R. ,  Gachanja, J. ,  Osaso, J. ,  Bishop, Richard P. ,  Morzaria, S.P. ,  [A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies] ,  A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies
Poster 2010-11-05

Autor: Patel, Ekta Lubembe, D. Gachanja, J. Mwaura, S. Spooner, P.R. Toye, Philip G.
Enlace original: https://cgspace.cgiar.org/handle/10568/2675

Investigación en Agricultura
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Patel, Ekta ,  Lubembe, D. ,  Gachanja, J. ,  Mwaura, S. ,  Spooner, P.R. ,  Toye, Philip G. ,  [Extensive genotypic diversity in the live sporozoite East Coast Fever (ITM) vaccine] ,  Extensive genotypic diversity in the live sporozoite East Coast Fever (ITM) vaccine
Journal Article 2011-04-15

Autor: Mwangi, D.M. Honda, Y. Graham, S.P. Pelle, Roger Taracha, E.L.N. Gachanja, J. Nyanjui, J.K. Bray, J. Palmer, G.H. Brown, W.C. Mwangi, W.

Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...

Enlace original: https://cgspace.cgiar.org/handle/10568/3074

Investigación en Agricultura
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Mwangi, D.M. ,  Honda, Y. ,  Graham, S.P. ,  Pelle, Roger ,  Taracha, E.L.N. ,  Gachanja, J. ,  Nyanjui, J.K. ,  Bray, J. ,  Palmer, G.H. ,  Brown, W.C. ,  Mwangi, W. ,  [Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses] ,  Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses
Journal Article 2011-06-30

Autor: Patel, Ekta Lubembe, D.M. Gachanja, J. Mwaura, S. Spooner, P.R. Toye, Philip G.

The current Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline. Immunization with a combination of parasite types has been shown to provide broader protection than i...

Enlace original: https://cgspace.cgiar.org/handle/10568/3166

Investigación en Agricultura
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Patel, Ekta ,  Lubembe, D.M. ,  Gachanja, J. ,  Mwaura, S. ,  Spooner, P.R. ,  Toye, Philip G. ,  [Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity] ,  Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity
Conference Paper 2006

Autor: Mwangi, D.M. Graham, S.P. Pelle, Roger Honda, Y. Tonukari, N.J. Yamage, I.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Abuya, E. Awino, Elias Gachanja, J. Luyai, A.E. Mbwika, F. Muthiani, A.M. Ndegwa, D.M. Njahira, Moses N. Nyanjui, J.K. Onono, F.O. Osaso, J. Saya, R.M. Wildmann, C. Fraser, C.M. Maudlin, I. Gardner, M.J. Morzaria, S.P. Loosmore, S. Gilbert, S.C. Audonnet, J.C. Bruggen, P. van der Nene, Vishvanath Taracha, E.L.N.

Theileria parva, a tick-borne api-complexan protozoan parasite, causes East Coast fever (ECF) in cattle. Control of the disease by improved vaccination is believed to provide a sustainable solution. Class I MHC-restricted CD8+ cytotoxic T lymphocytes (CTL) directed at schizontinfected cells const...

Enlace original: https://cgspace.cgiar.org/handle/10568/50513

Investigación en Agricultura
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Mwangi, D.M. ,  Graham, S.P. ,  Pelle, Roger ,  Honda, Y. ,  Tonukari, N.J. ,  Yamage, I.M. ,  Glew, E.J. ,  Villiers, Etienne P. de ,  Shah, Tushaar ,  Bishop, Richard P. ,  Abuya, E. ,  Awino, Elias ,  Gachanja, J. ,  Luyai, A.E. ,  Mbwika, F. ,  Muthiani, A.M. ,  Ndegwa, D.M. ,  Njahira, Moses N. ,  Nyanjui, J.K. ,  Onono, F.O. ,  Osaso, J. ,  Saya, R.M. ,  Wildmann, C. ,  Fraser, C.M. ,  Maudlin, I. ,  Gardner, M.J. ,  Morzaria, S.P. ,  Loosmore, S. ,  Gilbert, S.C. ,  Audonnet, J.C. ,  Bruggen, P. van der ,  Nene, Vishvanath ,  Taracha, E.L.N. ,  [Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?] ,  Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?
Journal Article 2008-02-15

Autor: Graham, S.P. Pelle, Roger Yamage, M. Mwangi, D.M. Honda, Y. Mwakubambanya, R.S. Villiers, Etienne P. de Abuya, E. Awino, Elias Gachanja, J. Mbwika, F. Muthiani, A.M. Muriuki, C. Nyanjui, J.K.

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells from T. parva-immune cattle of different major histocompatibility complex (MHC) genotypes have been identified, raising the prospect of d...

Enlace original: https://cgspace.cgiar.org/handle/10568/1480

Investigación en Agricultura
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Graham, S.P. ,  Pelle, Roger ,  Yamage, M. ,  Mwangi, D.M. ,  Honda, Y. ,  Mwakubambanya, R.S. ,  Villiers, Etienne P. de ,  Abuya, E. ,  Awino, Elias ,  Gachanja, J. ,  Mbwika, F. ,  Muthiani, A.M. ,  Muriuki, C. ,  Nyanjui, J.K. ,  [Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva] ,  Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva

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