The research objective was to develop a thermostable vaccine against peste des petits ruminants (PPR), a morbilliviral disease of small ruminants targeted for eradication that is a major constraint on the livelihoods of the rural poor throughout much of Africa and Asia. Although existing PPR vacc...
Mariner, Jeffrey C.
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Gachanja, J.
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Tindih, H.S.
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Toye, Philip G.
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[A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia]
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A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia
Previous studies using monoclonal antibody (mAb) 4C9 specific for a 32 kDa antigen (p32) of Theileria parva demonstrated expression of the antigen on the surface of the sporozoite, making it a potential antigen for sporozoite neutralization. A full-length cDNA encoding the major merozoite/piropla...
Skilton, Robert A.
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Musoke, A.J.
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Wells, C.W.
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Yagi, Y.
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Nene, Vishvanath
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Spooner, P.R.
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Gachanja, J.
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Osaso, J.
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Bishop, Richard P.
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Morzaria, S.P.
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[A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies]
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A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies
Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...
Mwangi, D.M.
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Honda, Y.
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Graham, S.P.
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Pelle, Roger
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Taracha, E.L.N.
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Gachanja, J.
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Nyanjui, J.K.
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Bray, J.
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Palmer, G.H.
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Brown, W.C.
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Mwangi, W.
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[Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses]
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Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses
The current Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline. Immunization with a combination of parasite types has been shown to provide broader protection than i...
Patel, Ekta
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Lubembe, D.M.
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Gachanja, J.
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Mwaura, S.
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Spooner, P.R.
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Toye, Philip G.
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[Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity]
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Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity
Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells from T. parva-immune cattle of different major histocompatibility complex (MHC) genotypes have been identified, raising the prospect of d...
Graham, S.P.
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Pelle, Roger
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Yamage, M.
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Mwangi, D.M.
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Honda, Y.
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Mwakubambanya, R.S.
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Villiers, Etienne P. de
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Abuya, E.
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Awino, Elias
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Gachanja, J.
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Mbwika, F.
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Muthiani, A.M.
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Muriuki, C.
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Nyanjui, J.K.
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[Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva]
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Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva