The research objective was to develop a thermostable vaccine against peste des petits ruminants (PPR), a morbilliviral disease of small ruminants targeted for eradication that is a major constraint on the livelihoods of the rural poor throughout much of Africa and Asia. Although existing PPR vacc...
Mariner, Jeffrey C.
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Gachanja, J.
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Tindih, H.S.
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Toye, Philip G.
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[A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia]
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A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia
Previous studies using monoclonal antibody (mAb) 4C9 specific for a 32 kDa antigen (p32) of Theileria parva demonstrated expression of the antigen on the surface of the sporozoite, making it a potential antigen for sporozoite neutralization. A full-length cDNA encoding the major merozoite/piropla...
Skilton, Robert A.
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Musoke, A.J.
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Wells, C.W.
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Yagi, Y.
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Nene, Vishvanath
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Spooner, P.R.
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Gachanja, J.
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Osaso, J.
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Bishop, Richard P.
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Morzaria, S.P.
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[A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies]
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A 32 kDa surface antigen of Theileria parva: Characterization and immunization studies
The current Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline. Immunization with a combination of parasite types has been shown to provide broader protection than i...
Patel, Ekta
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Lubembe, D.M.
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Gachanja, J.
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Mwaura, S.
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Spooner, P.R.
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Toye, Philip G.
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[Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity]
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Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity