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Infection of livestock with African trypanosomes leads to haematological changes such as anaemia and pancytopenia and to immune defects, including suppression of T-cell responsiveness and an excessive increase in the CD5+ B-cell population in blood and spleen. It has been shown that certain breed...


Mertens, B.Gaidulis, L.Mwangi, S.Suliman, H.Taylor, K.A.[Development of bovine-specific cytokine reagents at ILRAD]Development of bovine-specific cytokine reagents at ILRAD

T cells bearing the gamma delta antigen receptor (gamma delta T cells) can constitute up to 50 percent of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gamma delta T cells are involved in immune responses against Theileria parva. Gamma delta T c...


Daubenberger, C.A.Taracha, E.L.N.Gaidulis, L.Davis, W.C.McKeever, Declan J.[Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva]Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva

ILRAD outlined two different areas of research concern to the trypanosomiasis program. One goal was to identify trypanosomal antigens responsible for the immunopathogenesis of the disease by determining how the infection of cattle with trypanosomes affects their immune system. A second goal was...


McKeever, Declan J.Sileghem, M.R.Gardiner, Peter R.Gaidulis, L.[Summary of discussion]Summary of discussion

According to studies in human and mouse species it is apparent that both CD40 ligand and tumor necrosis factor alpha (TNF alpha) are members of a novel family of cytokines, referred to as the TNF - superfamily. This article reports the cloning of the cattle CD40 lignad and cattle TNF alpha, and s...


Mertens, B.Muriuki, C.Gaidulis, L.[Cloning of two members of the TNF - superfamily in cattle: CD40 ligand and tumor necrosis factor alpha]Cloning of two members of the TNF - superfamily in cattle: CD40 ligand and tumor necrosis factor alpha

This paper determines whether tumour necrosis factor (TNF alpha) (a cytokine that is predominantly secreted by cells of the monocyte/macrophage lineage) production is induced during bovine trypanosomiasis and wheather or not production is correlated with disease. TNF alpha titres in plasma from B...


Sileghem, M.R.Gaidulis, L.[Production of tumour necrosis factor alpha during bovine trypanosomiasis: possible correlation with severity of anaemia associated with the disease]Production of tumour necrosis factor alpha during bovine trypanosomiasis: possible correlation with severity of anaemia associated with the disease

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