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Isometamidium chloride has remained a very important prophylactic and therapeutic drug against trypanosomosis in cattle since its introduction into the market in the 1950s with, unfortunately, a concomitant development of resistance in trypanosomosis endemic areas. Amplified Fragment Length Polym...


Delespaux, V.Geysen, D.Majiwa, P.A.O.Geerts, S.[Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense]Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense

Testing of trypanocidal drug sensitivity in stabilates of pathogenic trypanosomes derived from cattle continues to be problematic, in spite of Development of in vitro techniques, since these are generally complicated and costly for the resources available in developing country laboratories. Furth...


Geerts, S.Ndung'u, J.M.Murilla, G.Mbwambo, H.Sinyangwe, L.Machila, N.Delespaux, V.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.Eisler, M.C.[A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice]A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice

In order to compare the prophylactic effect provided by a poly(D,L-lactide) sustained-release device (SRD) containing isometamidium (ISMM; Trypamidium) with that provided by the classical im injection of the drug, a field trial was carried out at the Madina Diassa Ranch in Mali, beginning in Nove...


Diarra, B.Diall, O.Geerts, S.Kageruka, P.Lemmouchi, Y.Schacht, E.Eisler, M.C.Holmes, P.[Field evaluation of the prophylactic effect of an isometamidium sustained-release device against trypanosomiasis in cattle]Field evaluation of the prophylactic effect of an isometamidium sustained-release device against trypanosomiasis in cattle

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