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A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...


Nilsson, P.H.Kang'a, S.Rottengatter, K.Suedbeck, U.Iraqui, F.Mwakaya, J.Mwangi, D.Womack, J.E.Goldammer, T.Schwerin, M.Bradley, D.Agaba, MorrisSugimoto, K.Gelhaus, A.Horstmann, R.Teale, A.J.Kemp, Stephen J.Hanotte, Olivier H.[Radiation hybrid maps of candidate trypanotolerance regions in cattle]Radiation hybrid maps of candidate trypanotolerance regions in cattle

Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and...


Hanotte, Olivier H.Ronin, Y.Agaba, MorrisNilsson, P.Gelhaus, A.Horstmann, R.Sugimoto, Y.Kemp, Stephen J.Gibson, John P.Korol, A.Soller, M.Teale, A.J.[Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle]Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle

A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populati...


Teale, A.J.Agaba, MorrisClapcott, S.J.Gelhaus, A.Haley, C.Psifidis, A.Horstmann, R.Iraqui, F.Kemp, Stephen J.Nilsson, P.Schwerin, M.Sekikawa, K.Soller, M.Sugimoto, Y.Womack, J.[Resistance to trypanosomosis: Of markers, genes and mechanisms]Resistance to trypanosomosis: Of markers, genes and mechanisms

Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous su...


Gelhaus, A.Hanotte, Olivier H.Horstmann, R.D.Teale, A.J.[Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene]Linkage mapping of the bovine lysosomal alphamannosidase (MANB) gene

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