A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...
Koudande, O.D.
,
Thomson, P.C.
,
Bovenhuis, H.
,
Iraqi, F.A.
,
Gibson, John P.
,
Arendonk, Johan A.M. van
,
[Biphasic survival analysis of trypanotolerance QTL in mice]
,
Biphasic survival analysis of trypanotolerance QTL in mice
A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens...
Behnke, J.M.
,
Menge, D.M.
,
Nagda, S.M.
,
Noyes, H.
,
Iraqi, F.A.
,
Kemp, Stephen J.
,
Mugambi, R.J.M.
,
Baker, R.L.
,
Wakelin, D.
,
Gibson, John P.
,
[Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice]
,
Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice
Over the past few years, research at ILRI and by its partners has identified genomic regions controlling trypanotolerance in cattle and in mice. In mice many of the genes lying within these genomic regions have been identified, leading the way to identification of the genes controlling trypanotol...
Some West African Bos taurus cattle breeds such as the N'Dama and a number of West African Shorthorns are resistant to tsetse fly-transmitted trypanosomosis. The trait is termed trypanotolerance, for which changes in packed red cell volume percent (PCV) and growth rate following infection are ge...
Waaij, E.H. van der
,
Hanotte, Olivier H.
,
Arendonk, Johan A.M. van
,
Kemp, Stephen J.
,
Kennedy, D.
,
Gibson, John P.
,
Teale, A.J.
,
[Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle]
,
Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle
Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...
Menge, D.M.
,
Behnke, J.M.
,
Iraqi, F.A.
,
Lowe, A.
,
Teale, A.J.
,
Gibson, John P.
,
Wakelin, D.
,
Baker, R.L.
,
[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]
,
Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice