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A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...


Koudande, O.D.Thomson, P.C.Bovenhuis, H.Iraqi, F.A.Gibson, John P.Arendonk, Johan A.M. van[Biphasic survival analysis of trypanotolerance QTL in mice]Biphasic survival analysis of trypanotolerance QTL in mice

Gibson, John P.Rege, J.E.O.Okeyo Mwai, AllyOjango, Julie M.K.[Overview of the Dairy Genetics East Africa (DGEA) project]Overview of the Dairy Genetics East Africa (DGEA) project

The polymorphism at the PvuII recognition site in the ESR gene showed no statistically significant association with sow productivity traits in a Meishan x Large White F2 population. Estimates of the effect on litter size were. however, in the opposite direction and statistically different from pr...


Gibson, John P.Jiang, Z.H.Robinson, J.A.B.Archibald, A.L.Haley, C.S.[No detectable association of the ESR Pvull mutation with sow productivity in a Meishan x Large White F2 population]No detectable association of the ESR Pvull mutation with sow productivity in a Meishan x Large White F2 population
Ojango, Julie M.K.Mrode, Raphael A.Rege, J.E.O.Mujibi, D.Strucken, E.M.Gibson, John P.Okeyo Mwai, Ally[Genetic evaluation of test-day milk yields from smallholder dairy production systems in Kenya using genomic relationships]Genetic evaluation of test-day milk yields from smallholder dairy production systems in Kenya using genomic relationships

Body linear measurements, and specifically heart girth (HG), have been shown to be useful predictors of cattle liveweight. To test the accuracy of body linear measurements for predicting liveweight, crossbred dairy cattle of different genotypes were measured and weighed. A total of 352 mature cow...


Lukuyu, Margaret N.Gibson, John P.Savage, D.B.Duncan, Alan J.Mujibi, F.D.N.Okeyo Mwai, Ally[Use of body linear measurements to estimate liveweight of crossbred dairy cattle in smallholder farms in Kenya]Use of body linear measurements to estimate liveweight of crossbred dairy cattle in smallholder farms in Kenya
Gibson, John P.[A coherent model for use of molecular genetic information for genetic improvement in low and medium input systems. Abstract]A coherent model for use of molecular genetic information for genetic improvement in low and medium input systems. Abstract

Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...


Kitani, H.Black, S.J.Nakamura, Y.Naessens, JanMurphy, N.Yokomizo, Y.Gibson, John P.Iraqi, F.A.[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures

About 30% of all farm animal breeds worldwide are at risk of extinction. To prevent this irreversible erosion of genetic diversity, the limited funds available for conservation need to be allocated in the most efficient way. Applying the diversity concept of Weitzman [Quart. J. Econ. CVII (1992) ...


Simianer, H.Marti, S.Gibson, John P.Hanotte, Olivier H.Rege, J.E.O.[An approach to the optimal allocation of conservation funds to minimize loss of genetic diversity between livestock breeds]An approach to the optimal allocation of conservation funds to minimize loss of genetic diversity between livestock breeds

Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and...


Hanotte, Olivier H.Ronin, Y.Agaba, MorrisNilsson, P.Gelhaus, A.Horstmann, R.Sugimoto, Y.Kemp, Stephen J.Gibson, John P.Korol, A.Soller, M.Teale, A.J.[Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle]Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle

To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-d...


O'Gorman, G.M.Park, S.D.E.Hill, E.W.Meade, K.G.Mitchell, L.C.Agaba, MorrisGibson, John P.Hanotte, Olivier H.Naessens, JanKemp, Stephen J.MacHugh, D.E.[Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense]Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense

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