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The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HS...


Nakamura, Y.Naessens, JanTakata, M.Taniguchi, T.Sekikawa, K.Gibson, John P.Iraqi, F.A.[Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection]Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection

Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much more sensitiv...


Noyes, H.A.Agaba, MorrisAnderson, S.Archibald, A.L.Brass, A.Gibson, John P.Hall, L.Hulme, H.Oh, S.J.Kemp, Stephen J.[Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background]Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

Microsatellite markers are commonly used for population genetic analyses of livestock. However, up to now, combinations of microsatellite data sets or Microsatellite markers are commonly used for population genetic analyses of livestock. However, up to now, combinations of microsatellite data set...


Freeman, A.R.Bradley, D.G.Nagda, S.M.Gibson, John P.Hanotte, Olivier H.[Combination of multiple microsatellite data sets to investigate genetic diversity and admixture of domestic cattle]Combination of multiple microsatellite data sets to investigate genetic diversity and admixture of domestic cattle

Fine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F6/F7 offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total wo...


Behnke, J.M.Iraqi, F.A.Mugambi, J.M.M.Clifford, S.Nagda, S.M.Wakelin, D.Kemp, Stephen J.Leyden, B.Gibson, John P.[High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice]High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice

Due to the absence of accurate pedigree information, it has not been possible to implement genetic evaluations for crossbred cattle in African small-holder systems. Genomic selection techniques that do not rely on pedigree information could, therefore, be a useful alternative. The objective of th...


Brown, A.Ojango, Julie M.K.Gibson, John P.Coffey, M.Okeyo Mwai, AllyMrode, Raphael A.[Short communication: Genomic selection in a crossbred cattle population using data from the Dairy Genetics East Africa Project]Short communication: Genomic selection in a crossbred cattle population using data from the Dairy Genetics East Africa Project

Mrode, Raphael A.Ojango, Julie M.K.Chinyere, E.Gibson, John P.Okeyo Mwai, Ally[Innovative digital technology and genomic approaches to dairy cattle genetic improvement in developing countries]Innovative digital technology and genomic approaches to dairy cattle genetic improvement in developing countries

This paper raises some issues on how genetics and genomics research at the International Livestock Research Institute (ILRI) can play a role in assisting livestock development in the region. Fundamentals of livestock production is outlined and the ILRI genetics and genomics research programme is ...


Gibson, John P.[Possible roles for ILRI genetics and genomics research]Possible roles for ILRI genetics and genomics research

Sons (n = 71 to 75) of each of six Holstein sires were genotyped at 69 microsatellite loci covering a total of 676 cM on chromosomes 3, 5, 9, 10, 13, 15, 17, 20, 23, and 26. Estimates of quantitative trait loci (QTL) effect and location were made using a least squares interval mapping approach ba...


Plante, Y.Gibson, John P.Nadesalingam, J.Mehrabani-Yeganeh, H.Lefebvre, S.Vandervoort, G.Jansen, G.B.[Detection of quantitative trait loci affecting milk production traits on 10 chromosomes in Holstein cattle]Detection of quantitative trait loci affecting milk production traits on 10 chromosomes in Holstein cattle
King, A.H.Jiang, Z.H.Rohrer, G.A.Gibson, John P.Waddington, D.Archibald, A.L.[Use of radiation hybrid mapping to locate candidate genes for female reproductive traits in porcine chromosome 8. Abstract]Use of radiation hybrid mapping to locate candidate genes for female reproductive traits in porcine chromosome 8. Abstract
Gibson, John P.Iraqi, F.A.[Are existing inbred strains a powerful resource for fine mapping of QTL? Inferences from observed haplotypes among 7 inbred strains]Are existing inbred strains a powerful resource for fine mapping of QTL? Inferences from observed haplotypes among 7 inbred strains

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