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Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...


Kitani, H.Black, S.J.Nakamura, Y.Naessens, JanMurphy, N.Yokomizo, Y.Gibson, John P.Iraqi, F.A.[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures

To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-d...


O'Gorman, G.M.Park, S.D.E.Hill, E.W.Meade, K.G.Mitchell, L.C.Agaba, MorrisGibson, John P.Hanotte, Olivier H.Naessens, JanKemp, Stephen J.MacHugh, D.E.[Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense]Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense

Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background...


Rathkolb, B.Noyes, H.A.Brass, A.Dark, P.Fuchs, H.Gailus-Durner, V.Gibson, John P.Angelis, M.H. deOgugo, M.Iraqi, F.A.Kemp, Stephen J.Naessens, JanPope, M.E.Wolf, E.Agaba, Morris[Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection]Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection

Some West African Bos taurus cattle breeds such as the N'Dama and a number of West African Shorthorns are resistant to tsetse fly-transmitted trypanosomosis. The trait is termed trypanotolerance, for which changes in packed red cell volume percent (PCV) and growth rate following infection are ge...


Waaij, E.H. van derHanotte, Olivier H.Arendonk, Johan A.M. vanKemp, Stephen J.Kennedy, D.Gibson, John P.Teale, A.J.[Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle]Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle

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