A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...
Koudande, O.D.
,
Thomson, P.C.
,
Bovenhuis, H.
,
Iraqi, F.A.
,
Gibson, John P.
,
Arendonk, Johan A.M. van
,
[Biphasic survival analysis of trypanotolerance QTL in mice]
,
Biphasic survival analysis of trypanotolerance QTL in mice
This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...
Kierstein, S.
,
Noyes, H.
,
Naessens, Jan
,
Nakamura, Y.
,
Pritchard, J.
,
Gibson, John P.
,
Kemp, Stephen J.
,
Brass, A.
,
[Gene expression profiling in a mouse model for African trypanosomiasis]
,
Gene expression profiling in a mouse model for African trypanosomiasis
Synthetic antimicrobial 9-mer peptides (designated as peptides A and B) designed on the basis of insect defensins and their effects on the growth of African trypanosomes were examined using two isolates of Trypanosoma congolense, IL1180 and IL3338, and two isolates of Trypanosoma brucei brucei, I...
Kitani, H.
,
Naessens, Jan
,
Kubo, M.
,
Nakamura, Y.
,
Iraqi, F.A.
,
Gibson, John P.
,
Yamakawa, M.
,
[Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture]
,
Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture
Over the past few years, research at ILRI and by its partners has identified genomic regions controlling trypanotolerance in cattle and in mice. In mice many of the genes lying within these genomic regions have been identified, leading the way to identification of the genes controlling trypanotol...
African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in t...
Goodhead, I.
,
Archibald, A.L.
,
Amwayi, P.
,
Brass, A.
,
Gibson, John P.
,
Hall, N.
,
Hughes, Monica A.
,
Limo, M.K.H.
,
Iraqi, F.A.
,
Kemp, Stephen J.
,
Noyes, H.A.
,
[A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice]
,
A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice
Some West African Bos taurus cattle breeds such as the N'Dama and a number of West African Shorthorns are resistant to tsetse fly-transmitted trypanosomosis. The trait is termed trypanotolerance, for which changes in packed red cell volume percent (PCV) and growth rate following infection are ge...
Waaij, E.H. van der
,
Hanotte, Olivier H.
,
Arendonk, Johan A.M. van
,
Kemp, Stephen J.
,
Kennedy, D.
,
Gibson, John P.
,
Teale, A.J.
,
[Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle]
,
Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle
Ng'ang'a, J.
,
Gibson, John P.
,
Imbuga, J.
,
Kemp, Stephen J.
,
Iraqi, F.A.
,
[Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract]
,
Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract
Macleod, A.K.
,
Iraqi, F.A.
,
Haley, C.S.
,
Gibson, John P.
,
[Using the false discovery rate in the detection of QTL for trypanosomiasis resistance in mice]
,
Using the false discovery rate in the detection of QTL for trypanosomiasis resistance in mice
Kierstein, S.
,
Noyes, H.A.
,
Nakamura, Y.
,
Naessens, Jan
,
Kemp, Stephen J.
,
Iraqi, F.A.
,
Gibson, John P.
,
[Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract]
,
Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract
Nakamura, Y.
,
Tsuchiya, Y.
,
Naessens, Jan
,
Gibson, John P.
,
Iraqi, F.A.
,
[Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract]
,
Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract