Commercial vaccines based on recombinant forms of the Bm86 tick gut antigen are used to control the southern cattle tick, Rhipicephalus microplus, a 1-host species, in Australia and Latin America. We describe herein sequence polymorphism in genes encoding Ra86 homologues of Bm86 in the brown ear ...
Kamau, L.M.
,
Skilton, Robert A.
,
Githaka, Naftaly W.
,
Kiara, Henry K.
,
Kabiru, E.
,
Shah, Tushaar
,
Musoke, A.J.
,
Bishop, Richard P.
,
[Extensive polymorphism of Ra86 genes in field populations of Rhipicephalus appendiculatus from Kenya]
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Extensive polymorphism of Ra86 genes in field populations of Rhipicephalus appendiculatus from Kenya
Inorganic PPases are essential metal-dependent enzymes that convert pyrophosphate into orthophosphate. This reaction is quite exergonic and provides a thermodynamic advantage for many ATP-driven biosynthetic reactions. We have previously demonstrated that cytosolic PPase from R. microplus embryos...
Costa, E.P.
,
Façanha, A.R.
,
Cruz, C.S.
,
Silva, J.N.
,
Machado, J.A.
,
Carvalho, G.M.
,
Fernandes, M.R.
,
Martins, R.
,
Campos, E.
,
Romeiro, N.C.
,
Githaka, Naftaly W.
,
Konnai, S.
,
Ohashi, K.
,
Vaz, I.S.
,
Logullo, C.
,
[A novel mechanism of functional cooperativity regulation by thiol redox status in a dimeric inorganic pyrophosphatase]
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A novel mechanism of functional cooperativity regulation by thiol redox status in a dimeric inorganic pyrophosphatase
Among arthropods, ticks lead as vectors of animal diseases and rank second to mosquitoes in transmitting human pathogens. Cyclin-dependent kinases (CDK) participate in cell cycle control in eukaryotes. CDKs are serine/threonine protein kinases and these catalytic subunits are activated or inactiv...
Gomes, H.
,
Moraes, J.
,
Githaka, Naftaly W.
,
Martins, R.
,
Isezaki, M.
,
Silva Vaz, I. da
,
Logullo, C.
,
Konnai, S.
,
Ohashi, K.
,
[Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation]
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Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation
Githaka, Naftaly W.
,
Odongo, D.
,
Lekolool, I.
,
Konnai, S.
,
Bishop, Richard P.
,
[Novel Theileria genotypes from wildlife in a Theileria parva—Endemic area in Kenya]
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Novel Theileria genotypes from wildlife in a Theileria parva—Endemic area in Kenya
The tick population of Africa includes several important genera belonging to the family Ixodidae. Many of these ticks are vectors of protozoan and rickettsial pathogens including Theileria parva that causes East Coast fever, a debilitating cattle disease endemic to eastern, central and southern A...
Rothen, J.
,
Githaka, Naftaly W.
,
Kanduma, E.G.
,
Olds, Cassandra L.
,
Pflueger, V.
,
Mwaura, S.
,
Bishop, Richard P.
,
Daubenberger, C.A.
,
[Matrix-assisted laser desorption/ionization time of flight mass spectrometry for comprehensive indexing of East African Ixodid tick species]
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Matrix-assisted laser desorption/ionization time of flight mass spectrometry for comprehensive indexing of East African Ixodid tick species
Githaka, Naftaly W.
,
Konnai, S.
,
Bishop, Richard P.
,
Odongo, D.
,
Lekolool, I.
,
Kariuki, E.
,
Gakuya, F.
,
Kamau, L.
,
Isezaki, M.
,
Murata, S.
,
Ohashi, K.
,
[Identification and sequence characterization of novel Theileria genotypes from the waterbuck (Kobus defassa) in a Theileria parva-endemic area in Kenya]
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Identification and sequence characterization of novel Theileria genotypes from the waterbuck (Kobus defassa) in a Theileria parva-endemic area in Kenya
The ticks Rhipicephalus appendiculatus and Rhipicephalus sanguineus are the main vectors of Theileria parva and Babesia spp. in cattle and dogs, respectively. Due to their impact in veterinary care and industry, improved methods against R. appendiculatus and R. sanguineus parasitism are under dev...
Sabadin, G.A.
,
Parizi, L.F.
,
Kiio, I.
,
Xavier, M.A.
,
Silva Matos, R. da
,
Camargo-Mathias, M.I.
,
Githaka, Naftaly W.
,
Nene, Vishvanath
,
Silva Vaz, I. da
,
[Effect of recombinant glutathione S-transferase as vaccine antigen against Rhipicephalus appendiculatus and Rhipicephalus sanguineus infestation]
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Effect of recombinant glutathione S-transferase as vaccine antigen against Rhipicephalus appendiculatus and Rhipicephalus sanguineus infestation