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Journal Article 2018-04-23

Autor: Schwartz, J.C. Hemmink, J.D. Graham, S.P. Tchilian, E. Charleston, B. Hammer, S.E. Ho, C.S. Hammond, J.A.
Enlace original: https://cgspace.cgiar.org/handle/10568/99010

Investigación en Agricultura
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Schwartz, J.C. ,  Hemmink, J.D. ,  Graham, S.P. ,  Tchilian, E. ,  Charleston, B. ,  Hammer, S.E. ,  Ho, C.S. ,  Hammond, J.A. ,  [The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine] ,  The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
Journal Article 2011-04-29

Autor: Pelle, Roger Graham, S.P. Njahira, Moses N. Osaso, J. Saya, R.M. Odongo, David O. Toye, Philip G. Spooner, P.R. Musoke, A.J. Mwangi, D.M. Taracha, E.L.N. Morrison, W. Ivan Weir, W. Silva, J. Bishop, Richard P.

Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...

Enlace original: https://cgspace.cgiar.org/handle/10568/3780

Investigación en Agricultura
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Pelle, Roger ,  Graham, S.P. ,  Njahira, Moses N. ,  Osaso, J. ,  Saya, R.M. ,  Odongo, David O. ,  Toye, Philip G. ,  Spooner, P.R. ,  Musoke, A.J. ,  Mwangi, D.M. ,  Taracha, E.L.N. ,  Morrison, W. Ivan ,  Weir, W. ,  Silva, J. ,  Bishop, Richard P. ,  [Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity] ,  Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
Journal Article 2016-07-15

Autor: Hemmink, J.D. Weir, W. MacHugh, Niall D. Graham, S.P. Patel, Ekta Paxton, E. Shiels, B. Toye, Philip G. Morrison, W. Ivan Pelle, Roger

An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions ...

Enlace original: https://cgspace.cgiar.org/handle/10568/73303

Investigación en Agricultura
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Hemmink, J.D. ,  Weir, W. ,  MacHugh, Niall D. ,  Graham, S.P. ,  Patel, Ekta ,  Paxton, E. ,  Shiels, B. ,  Toye, Philip G. ,  Morrison, W. Ivan ,  Pelle, Roger ,  [Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva] ,  Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva
Journal Article 2005-08-19

Autor: Bishop, Richard P. Shah, Tushaar Pelle, Roger Hoyle, D. Pearson, T. Haines, L. Brass, A. Hulme, H. Graham, S.P. Taracha, E.L.N. Lu, C. Hass, B. Wortman, J. White, O. Gardner, M.J. Nene, Vishvanath Villiers, Etienne P. de

Massively parallel signature sequencing (MPSS) was used to analyze the transcriptome of the intracellular protozoan Theileria parva. In total 1 095 000, 20 bp sequences representing 4371 different signatures were generated from T.parva schizonts. Reproducible signatures were identified within 73%...

Enlace original: https://cgspace.cgiar.org/handle/10568/21180

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Bishop, Richard P. ,  Shah, Tushaar ,  Pelle, Roger ,  Hoyle, D. ,  Pearson, T. ,  Haines, L. ,  Brass, A. ,  Hulme, H. ,  Graham, S.P. ,  Taracha, E.L.N. ,  Lu, C. ,  Hass, B. ,  Wortman, J. ,  White, O. ,  Gardner, M.J. ,  Nene, Vishvanath ,  Villiers, Etienne P. de ,  [Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage] ,  Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
Journal Article 2006-02-28

Autor: Graham, S.P. Pelle, Roger Honda, Y. Mwangi, D.M. Tonukari, N.J. Yamage, M. Glew, E.J. Villiers, Etienne P. de

East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-i...

Enlace original: https://cgspace.cgiar.org/handle/10568/1406

Investigación en Agricultura
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Graham, S.P. ,  Pelle, Roger ,  Honda, Y. ,  Mwangi, D.M. ,  Tonukari, N.J. ,  Yamage, M. ,  Glew, E.J. ,  Villiers, Etienne P. de ,  [Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes] ,  Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
Journal Article 2007-02-09

Autor: Graham, S.P. Honda, Y. Pelle, Roger Mwangi, D.M. Glew, E.J. Villiers, Etienne P. de Shah, Tushaar Bishop, Richard P. Bruggen, P. van der Nene, Vishvanath Taracha, E.L.N.

Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development ...

Enlace original: https://cgspace.cgiar.org/handle/10568/1394

Investigación en Agricultura
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Graham, S.P. ,  Honda, Y. ,  Pelle, Roger ,  Mwangi, D.M. ,  Glew, E.J. ,  Villiers, Etienne P. de ,  Shah, Tushaar ,  Bishop, Richard P. ,  Bruggen, P. van der ,  Nene, Vishvanath ,  Taracha, E.L.N. ,  [A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology] ,  A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
Journal Article 2009-09-15

Autor: MacHugh, Niall D. Connelley, T. Graham, S.P. Pelle, Roger Formisano, P. Taracha, E.L.N. Ellis, S.A. McKeever, Declan J. Burrells, A. Morrison, W. Ivan

Although immunodominance of CD8+ T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear. In previous studies we have observed that CD8+ T-cell responses to Theileria parva exhibit different patterns of parasit...

Enlace original: https://cgspace.cgiar.org/handle/10568/342

Investigación en Agricultura
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MacHugh, Niall D. ,  Connelley, T. ,  Graham, S.P. ,  Pelle, Roger ,  Formisano, P. ,  Taracha, E.L.N. ,  Ellis, S.A. ,  McKeever, Declan J. ,  Burrells, A. ,  Morrison, W. Ivan ,  [CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity] ,  CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity
Journal Article 2008-02-15

Autor: Akoolo, L. Pelle, Roger Saya, R. Awino, Elias Nyanjui, J. Taracha, E.L.N. Kanyari, P. Mwangi, D.M. Graham, S.P.

East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...

Enlace original: https://cgspace.cgiar.org/handle/10568/1942

Investigación en Agricultura
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Akoolo, L. ,  Pelle, Roger ,  Saya, R. ,  Awino, Elias ,  Nyanjui, J. ,  Taracha, E.L.N. ,  Kanyari, P. ,  Mwangi, D.M. ,  Graham, S.P. ,  [Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle] ,  Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
Journal Article 2009-03-15

Autor: Graham, S.P. Pelle, Roger Villiers, Etienne P. de Yamage, M. Mwangi, D.M. Honda, Y. Ellis, S.A. MacHugh, Niall D. Morrison, W. Ivan Taracha, E.L.N.

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...

Enlace original: https://cgspace.cgiar.org/handle/10568/32

Investigación en Agricultura
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Graham, S.P. ,  Pelle, Roger ,  Villiers, Etienne P. de ,  Yamage, M. ,  Mwangi, D.M. ,  Honda, Y. ,  Ellis, S.A. ,  MacHugh, Niall D. ,  Morrison, W. Ivan ,  Taracha, E.L.N. ,  [Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva] ,  Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva
Journal Article 2011-04-15

Autor: Mwangi, D.M. Honda, Y. Graham, S.P. Pelle, Roger Taracha, E.L.N. Gachanja, J. Nyanjui, J.K. Bray, J. Palmer, G.H. Brown, W.C. Mwangi, W.

Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...

Enlace original: https://cgspace.cgiar.org/handle/10568/3074

Investigación en Agricultura
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Mwangi, D.M. ,  Honda, Y. ,  Graham, S.P. ,  Pelle, Roger ,  Taracha, E.L.N. ,  Gachanja, J. ,  Nyanjui, J.K. ,  Bray, J. ,  Palmer, G.H. ,  Brown, W.C. ,  Mwangi, W. ,  [Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses] ,  Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses

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