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Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...


Pelle, RogerGraham, S.P.Njahira, Moses N.Osaso, J.Saya, R.M.Odongo, David O.Toye, Philip G.Spooner, P.R.Musoke, A.J.Mwangi, D.M.Taracha, E.L.N.Morrison, W. IvanWeir, W.Silva, J.Bishop, Richard P.[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity

Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymor...


Graham, S.P.Saya, R.Awino, EliasNgugi, D.Nyanjui, J.K.Hecker, R.Taracha, E.L.N.Nene, Vishvanath[Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva]Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
Mwangi, D.M.Graham, S.P.Pelle, RogerHonda, Y.Tonukari, N.J.Yamage, I.M.Glew, E.J.Villiers, Etienne P. deShah, TushaarBishop, Richard P.Abuya, E.Awino, EliasGachanja, J.Luyai, A.E.Mbwika, F.Muthiani, A.M.Ndegwa, D.M.Njahira, Moses N.Nyanjui, J.K.Onono, F.O.Osaso, J.Saya, R.M.Wildmann, C.Fraser, C.M.Maudlin, I.Gardner, M.J.Morzaria, S.P.Loosmore, S.Gilbert, S.C.Audonnet, J.C.Bruggen, P. van derNene, VishvanathTaracha, E.L.N.[Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?]Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?

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