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Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...


Pelle, RogerGraham, S.P.Njahira, Moses N.Osaso, J.Saya, R.M.Odongo, David O.Toye, Philip G.Spooner, P.R.Musoke, A.J.Mwangi, D.M.Taracha, E.L.N.Morrison, W. IvanWeir, W.Silva, J.Bishop, Richard P.[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity

An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions ...


Hemmink, J.D.Weir, W.MacHugh, Niall D.Graham, S.P.Patel, EktaPaxton, E.Shiels, B.Toye, Philip G.Morrison, W. IvanPelle, Roger[Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva]Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva

East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-i...


Graham, S.P.Pelle, RogerHonda, Y.Mwangi, D.M.Tonukari, N.J.Yamage, M.Glew, E.J.Villiers, Etienne P. de[Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes]Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes

Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development ...


Graham, S.P.Honda, Y.Pelle, RogerMwangi, D.M.Glew, E.J.Villiers, Etienne P. deShah, TushaarBishop, Richard P.Bruggen, P. van derNene, VishvanathTaracha, E.L.N.[A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology]A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology

Theileria parva antigens recognized by cytotoxic T lymphocytes (CTLs) are prime vaccine candidates against East Coast Fever in cattle. A strategy for enhancing induction of parasite-specific T cell responses by increasing recruitment and activation of dendritic cells (DCs) at the immunization sit...


Mwangi, D.M.Honda, Y.Graham, S.P.Pelle, RogerTaracha, E.L.N.Gachanja, J.Nyanjui, J.K.Bray, J.Palmer, G.H.Brown, W.C.Mwangi, W.[Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses]Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses
Bishop, Richard P.Odongo, David O.Mann, D.J.Pearson, T.W.Sugimoto, C.Haines, L.R.Glass, E.Jensen, K.Seitzer, U.Ahmed, J.S.Graham, S.P.Villiers, Etienne P. de[Theileria]Theileria

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