Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from addition...
Gorkhali, N.A.
,
Kunzhe Dong
,
Min Yang
,
Shen Song
,
Kader, A.
,
Shrestha, B.S.
,
Xiaohong He
,
Qian-Jun Zhao
,
Yabin Pu
,
Xiangchen Li
,
Kijas, J.
,
Weijun, Guan
,
Han Jianlin
,
Lin Jiang
,
Yuehui Ma
,
[Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas]
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Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas
Xiao-Ju Hu
,
Ji Yang
,
Xing-Long Xie
,
Feng-Hua Lv
,
Yin-Hong Cao
,
Wen-Rong Li
,
Ming-Jun Liu
,
Yu-Tao Wang
,
Jin-Quan Li
,
Yong-Gang Liu
,
Yan-Lin Ren
,
Zhi-Qiang Shen
,
Han Jianlin
,
Meng-Hua Li
,
[The genome landscape of Tibetan sheep reveals adaptive introgression from argali and the history of early human settlements on the Qinghai-Tibetan Plateau]
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The genome landscape of Tibetan sheep reveals adaptive introgression from argali and the history of early human settlements on the Qinghai-Tibetan Plateau
PCR-SSCP and DNA sequencing approaches were applied to assess the single nucleotide polymorphisms (SNPs) and analyze the genetic polymorphisms at partial exon 2 and intron 2 of H-FABP(Heart fatty acid-binding protein)gene, and five sheep populations that comprised of Small-Tailed Han sheep (SH, 4...
Qiao, H.Y.
,
Zhao, Q.J.
,
Yao, N.
,
Lu, Y.-Z.
,
Meng, X.-R.
,
Guan, Wei-Jun
,
Ma, Y.H.
,
Han Jianlin
,
[Study on single nucleotide polymorphisms of H -FABP gene in sheep]
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Study on single nucleotide polymorphisms of H -FABP gene in sheep
Heteroplasmy due to length polymorphism with tandem repeats in mtDNAs within individual was hardly studied in domestic animals. In the present study, we identified intra-individual length variation in the control region of mtDNAs in Nepalese sheep by molecular cloning and sequencing techniques. W...
Gorkhali, N.A.
,
Lin Jiang
,
Shrestha, B.S.
,
Xiao-Hong He
,
Qian-Jun Zhao
,
Han Jianlin
,
Yue-Hui Ma
,
[High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep]
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High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep
MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...
Qian-Jun Zhao
,
Ye Kang
,
Hong-Yang Wang
,
Weijun, Guan
,
Xiang-Chen Li
,
Lin Jiang
,
Xiao-Hong He
,
Yabin Pu
,
Han Jianlin
,
Yue-Hui Ma
,
Qian-Jun Zhao
,
[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]
,
Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development
Genotype data from eight microsatellite markers were used to assess genetic diversity and relationships among five indigenous Bhutanese sheep populations, Sakten, Jakar, Sarpang, Sipsu and Tsirang. Estimates of mean observed and expected heterozygosities, mean number of alleles per locus/populati...
Tashi, D.
,
Wafula, P.
,
Yoshio, Y.
,
Shinji, S.
,
Kenji, O.
,
Hanotte, Olivier H.
,
Bang-Zhong, L.
,
Hideyuki, M.
,
Han Jianlin
,
[Sheep genetic diversity in Bhutan using microsatellite markers]
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Sheep genetic diversity in Bhutan using microsatellite markers
Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become...
Ji Yang
,
Wen-Rong Li
,
Feng-Hua Lv
,
San-Gang He
,
Shi-Lin Tian
,
Wei-Feng Peng
,
Ya-Wei Sun
,
Yong-Xin Zhao
,
Xiao-Long Tu
,
Min Zhang
,
Xing-Long Xie
,
Yu-Tao Wang
,
Jin-Quan Li
,
Yong-Gang Liu
,
Zhi-Qiang Shen
,
Feng Wang
,
Guang-Jian Liu
,
Hong-Feng Lu
,
Juha Kantanen
,
Han Jianlin
,
Meng-Hua Li
,
Ming-Jun Liu
,
[Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments]
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Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments
Despite much attention, history of sheep (Ovis aries) evolution, including its dating, demographic trajectory and geographic spread, remains controversial. To address these questions, we generated 45 complete and 875 partial mitogenomic sequences, and performed a meta-analysis of these and publis...
Feng-Hua Lv
,
Wei-Feng Peng
,
Ji Yang
,
Yong-Xin Zhao
,
Wen-Rong Li
,
Ming-Jun Liu
,
Yue-Hui Ma
,
Qian-Jun Zhao
,
Guang-Li Yang
,
Feng Wang
,
Jin-Quan Li
,
Yong-Gang Liu
,
Zhi-Qiang Shen
,
Sheng-Guo Zhao
,
EEr Hehua
,
Gorkhali, N.A.
,
Farhad Vahidi, S.M.
,
Muladno, M.
,
Naqvi, A.N.
,
Tabell, J.
,
Iso-Touru, T.
,
Bruford, M.W.
,
Kantanen, J.
,
Han Jianlin
,
Meng-Hua Li
,
[Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep]
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Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep
The genetic consequences of population differentiation and isolation have been the subject of conservation biology. In this study, we analysed the genetic diversity and structure of Mongolian sheep in China. These animals belong to a traditional local breed with high production, extensive adaptio...