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Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from addition...


Gorkhali, N.A.Kunzhe DongMin YangShen SongKader, A.Shrestha, B.S.Xiaohong HeQian-Jun ZhaoYabin PuXiangchen LiKijas, J.Weijun, GuanHan JianlinLin JiangYuehui Ma[Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas]Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas
Xiao-Ju HuJi YangXing-Long XieFeng-Hua LvYin-Hong CaoWen-Rong LiMing-Jun LiuYu-Tao WangJin-Quan LiYong-Gang LiuYan-Lin RenZhi-Qiang ShenHan JianlinMeng-Hua Li[The genome landscape of Tibetan sheep reveals adaptive introgression from argali and the history of early human settlements on the Qinghai-Tibetan Plateau]The genome landscape of Tibetan sheep reveals adaptive introgression from argali and the history of early human settlements on the Qinghai-Tibetan Plateau

PCR-SSCP and DNA sequencing approaches were applied to assess the single nucleotide polymorphisms (SNPs) and analyze the genetic polymorphisms at partial exon 2 and intron 2 of H-FABP(Heart fatty acid-binding protein)gene, and five sheep populations that comprised of Small-Tailed Han sheep (SH, 4...


Qiao, H.Y.Zhao, Q.J.Yao, N.Lu, Y.-Z.Meng, X.-R.Guan, Wei-JunMa, Y.H.Han Jianlin[Study on single nucleotide polymorphisms of H -FABP gene in sheep]Study on single nucleotide polymorphisms of H -FABP gene in sheep

Heteroplasmy due to length polymorphism with tandem repeats in mtDNAs within individual was hardly studied in domestic animals. In the present study, we identified intra-individual length variation in the control region of mtDNAs in Nepalese sheep by molecular cloning and sequencing techniques. W...


Gorkhali, N.A.Lin JiangShrestha, B.S.Xiao-Hong HeQian-Jun ZhaoHan JianlinYue-Hui Ma[High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep]High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep

MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...


Qian-Jun ZhaoYe KangHong-Yang WangWeijun, GuanXiang-Chen LiLin JiangXiao-Hong HeYabin PuHan JianlinYue-Hui MaQian-Jun Zhao[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development

Genotype data from eight microsatellite markers were used to assess genetic diversity and relationships among five indigenous Bhutanese sheep populations, Sakten, Jakar, Sarpang, Sipsu and Tsirang. Estimates of mean observed and expected heterozygosities, mean number of alleles per locus/populati...


Tashi, D.Wafula, P.Yoshio, Y.Shinji, S.Kenji, O.Hanotte, Olivier H.Bang-Zhong, L.Hideyuki, M.Han Jianlin[Sheep genetic diversity in Bhutan using microsatellite markers]Sheep genetic diversity in Bhutan using microsatellite markers

Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become...


Ji YangWen-Rong LiFeng-Hua LvSan-Gang HeShi-Lin TianWei-Feng PengYa-Wei SunYong-Xin ZhaoXiao-Long TuMin ZhangXing-Long XieYu-Tao WangJin-Quan LiYong-Gang LiuZhi-Qiang ShenFeng WangGuang-Jian LiuHong-Feng LuJuha KantanenHan JianlinMeng-Hua LiMing-Jun Liu[Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments]Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments

Despite much attention, history of sheep (Ovis aries) evolution, including its dating, demographic trajectory and geographic spread, remains controversial. To address these questions, we generated 45 complete and 875 partial mitogenomic sequences, and performed a meta-analysis of these and publis...


Feng-Hua LvWei-Feng PengJi YangYong-Xin ZhaoWen-Rong LiMing-Jun LiuYue-Hui MaQian-Jun ZhaoGuang-Li YangFeng WangJin-Quan LiYong-Gang LiuZhi-Qiang ShenSheng-Guo ZhaoEEr HehuaGorkhali, N.A.Farhad Vahidi, S.M.Muladno, M.Naqvi, A.N.Tabell, J.Iso-Touru, T.Bruford, M.W.Kantanen, J.Han JianlinMeng-Hua Li[Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep]Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep

The genetic consequences of population differentiation and isolation have been the subject of conservation biology. In this study, we analysed the genetic diversity and structure of Mongolian sheep in China. These animals belong to a traditional local breed with high production, extensive adaptio...


Zhong, T.Han JianlinGuo, J.Zhao, Q.J.Fu, B.L.Pu, Y.B.He, X.H.Jeon, J.T.Guan, Wei-JunMa, Y.H.[Tracing genetic differentiation of Chinese Mongolian sheep using microsatellites]Tracing genetic differentiation of Chinese Mongolian sheep using microsatellites

China has a rich resource of native sheep (Ovis aries) breeds associated with historical movements of several nomadic societies. However, the history of sheep and the associated nomadic societies in ancient China remains poorly understood. Here, we studied the genomic diversity of Chinese sheep u...


Yong-Xin ZhaoJi YangFeng-Hua LvXiao-Ju HuXing-Long XieMin ZhangWen-Rong LiMing-Jun LiuYu-Tao WangJin-Quan LiYong-Gang LiuYan-Ling RenFeng WangEEr HehuaJuha KantanenLenstra, J.A.Han JianlinMeng-Hua Li[Genomic reconstruction of the history of native sheep reveals the peopling patterns of nomads and the expansion of early pastoralism in East Asia]Genomic reconstruction of the history of native sheep reveals the peopling patterns of nomads and the expansion of early pastoralism in East Asia

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